Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tyrosine kinase inhibitor 是酪氨酸激酶的有效抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,570 | 5日内发货 | ||
5 mg | ¥ 2,660 | 5日内发货 | ||
10 mg | ¥ 3,970 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,430 | 5日内发货 |
产品描述 | Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents. |
体外活性 | Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli. Recent advances have implicated the role of tyrosine kinases in the pathophysiology of cancer. Though their activity is tightly regulated in normal cells, they may acquire transforming functions due to mutation(s), overexpression and autocrine paracrine stimulation, leading to malignancy. Constitutive oncogenic activation in cancer cells can be blocked by selective tyrosine kinase inhibitors and thus considered as a promising approach for innovative genome based therapeutics. |
分子量 | 586.61 |
分子式 | C31H31FN6O5 |
CAS No. | 1021950-26-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (76.71 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7047 mL | 8.5236 mL | 17.0471 mL | 42.6178 mL |
5 mM | 0.3409 mL | 1.7047 mL | 3.4094 mL | 8.5236 mL | |
10 mM | 0.1705 mL | 0.8524 mL | 1.7047 mL | 4.2618 mL | |
20 mM | 0.0852 mL | 0.4262 mL | 0.8524 mL | 2.1309 mL | |
50 mM | 0.0341 mL | 0.1705 mL | 0.3409 mL | 0.8524 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tyrosine kinase inhibitor 1021950-26-4 Tyrosine Kinase/Adaptors c-Met/HGFR Tyrosine Kinases Inhibitor inhibit kinases tyrosine inhibitor