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SB290157 trifluoroacetate

SB290157 trifluoroacetate

产品编号 T12851   CAS 1140525-25-2

SB290157 trifluoroacetate 是一种选择性 C3a 受体拮抗剂,IC50值为200 nM。

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SB290157 trifluoroacetate Chemical Structure
SB290157 trifluoroacetate, CAS 1140525-25-2
规格 价格/CNY 货期 数量
1 mg ¥ 223 现货
5 mg ¥ 497 现货
10 mg ¥ 797 现货
25 mg ¥ 1,620 现货
50 mg ¥ 2,820 现货
100 mg ¥ 4,180 现货
1 mL * 10 mM (in DMSO) ¥ 576 现货
产品目录号及名称: SB290157 trifluoroacetate (T12851)
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纯度: 98.93%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).
靶点活性 C3a:200 nM
体外活性 SB 290157 is a competitive antagonist of 125I-C3a radioligand binding to rat basophilic leukemia-2H3 cells expressing the human C3aR (RBL-C3aR, IC50 of 200 nM). SB 290157 blocks C3a-induced C3aR internalization in a concentration-dependent manner and C3a-induced Ca2+ mobilization in RBL-C3aR cells and human neutrophils (IC50s of 27.7 and 28 nM, respectively). SB 290157 is selective for the C3aR in that. SB 290157 also inhibits C3a-induced Ca2+ mobilization of RBL-2H3 cells expressing the mouse and guinea pig C3aRs. It potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery[1].
体内活性 Neutrophil recruitment in a guinea pig LPS-induced airway neutrophilia model inhibited by SB 290157 ,SB 290157 decreases paw edema in a rat adjuvant-induced arthritis model[1]. The antagonist is able to reduce joint swelling only at 3 h, and about 50% inhibition of joint swelling is observed with the concentration of 30 mg/kg. The C3 level is significantly decreased at 3 h compared with naive mice showing complement consumption. Furthermore, the C3 activation is observed and increased corresponding to the graded concentration of anti-OVA pAb[2].
分子量 526.51
分子式 C24H29F3N4O6
CAS No. 1140525-25-2

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 125 mg/mL (237.41 mM), sonification is recommended.

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8993 mL 9.4965 mL 18.993 mL 47.4825 mL
5 mM 0.3799 mL 1.8993 mL 3.7986 mL 9.4965 mL
10 mM 0.1899 mL 0.9496 mL 1.8993 mL 4.7482 mL
20 mM 0.095 mL 0.4748 mL 0.9496 mL 2.3741 mL
50 mM 0.038 mL 0.1899 mL 0.3799 mL 0.9496 mL
100 mM 0.019 mL 0.095 mL 0.1899 mL 0.4748 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Ames RS, et al. Identification of a selective nonpeptide antagonist of the anaphylatoxin C3areceptor that demonstrates antiinflammatory activity in animal models. J Immunol. 2001 May 15;166(10):6341-8. 2. Hutamekalin P, et al. Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonalantibody-induced arthritis. J Pharmacol Sci. 2010;112(1):56-63.
(Z)-Leukadherin-1 Compstatin 3-Phenoxybenzaldehyde NDT 9513727 NH2-C6-ARC186 TLQP 21 acetate Tesidolumab Compstatin control peptide acetate

相关化合物库

该产品包含在如下化合物库中:
已知活性化合物库 经典已知活性库 NO PAINS 化合物库 抑制剂库 免疫/炎症分子化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

SB290157 trifluoroacetate 1140525-25-2 Immunology/Inflammation Complement System SB290157 Trifluoroacetate SB290157 SB-290157 trifluoroacetate Inhibitor SB 290157 Trifluoroacetate inhibit SB 290157 SB-290157 SB-290157 Trifluoroacetate inhibitor

 

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