keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IRL-1620 acetate 是一种有效的特异性内啡肽 B 受体 (ETB) 激动剂,Ki 为 16 pM,相比于ETA,其Ki 为 19 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,490 | 现货 | ||
5 mg | ¥ 3,760 | 现货 | ||
10 mg | ¥ 5,380 | 现货 | ||
25 mg | ¥ 8,360 | 现货 | ||
50 mg | ¥ 11,200 | 现货 | ||
100 mg | ¥ 14,900 | 现货 |
产品描述 | IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM. |
靶点活性 | ETB receptor:16 pM(Ki), ETA receptor:19 μM(Ki) |
体外活性 | IRL-1620 acetate is 60 times more selective for the ETB receptor than ET-3 (KiETA/ KiETB=1900)[3]. |
体内活性 | IRL-1620 acetate improves both acquisition (learning) and retention (memory) on the water maze task and enhances angiogenic and neurogenic remodeling. Rats treated with IRL-1620 acetate significantly reduces the cognitive impairment induced by Aβ. IRL-1620 acetate treatment enhances the number of blood vessels labeled with VEGF compared to vehicle treatment[1]. IRL-1620 acetate, restores analgesic tolerance to morphine and oxycodone, but it does not affect morphine and oxycodone induced decrease in NGF/PI3K expression. IRL-1620 acetate attenuates opioid tolerance without the involvement of NGF/PI3K pathway[2]. IRL-1620 acetate (1-100 nM) induces contractions of the guinea pig trachea. The effective concentration that produces 30 % of 60 mM KCI-induced contraction is estimated to be 28 nM for IRL 1620[3]. IRL-1620 acetate (1-100 nM) increases cytosolic Ca2+ in the vascular endothelium ([Ca]E) with little effect on resting muscle tone, and relaxes the norepinephrine-stimulated tone with an increase in [Ca]E, in rat aorta[3]. |
别名 | IRL-1620 acetate(142569-99-1 free base) |
分子量 | 1881 |
分子式 | C88H121N17O29 |
CAS No. | T15595L |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IRL-1620 acetate T15595L GPCR/G Protein Endothelin Receptor IRL1620 acetate IRL 1620 Acetate IRL1620 Acetate 142569-99-1 free base IRL-1620 acetate(142569-99-1 free base) IRL-1620 Acetate 142569-99-1 IRL 1620 acetate Inhibitor inhibitor inhibit