Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) 是一种 Na+/Ca2+ 交换抑制剂,抑制 Na+ 诱导的豚鼠心脏线粒体中 Ca2+ 的释放,IC50 为 0.8 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 398 | 现货 | ||
10 mg | ¥ 697 | 现货 | ||
25 mg | ¥ 1,240 | 现货 | ||
50 mg | ¥ 2,137 | 现货 | ||
100 mg | ¥ 3,422 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 448 | 现货 |
产品描述 | CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM. |
靶点活性 | Na+, Ca2+ exchanger:0.8 μM |
体外活性 | Administration of 10?μM CGP37157 shows an inhibitory effect on mitochondrial Na+/Ca2+ exchanger in cortical neurons, modulating intracellular Ca2+ levels via suppressing voltage-gated calcium channels. Administration of 10?μM CGP37157 in combination with salinomycin significantly attenuates cell viability and increases apoptosis of FaDu and HLaC79 cells. CGP37157 has no inhibitory effect on salinomycin tumor toxicity[2]. Administration of 10?μM CGP37157 reduces NMDA-induced cytosolic and mitochondrial Ca2+ overloads and it also reduces NMDA-induced excitotoxicity, and such an effect is via attenuating mitochondrial damage and calpain activity in neurons[3]. |
别名 | 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one |
分子量 | 324.22 |
分子式 | C15H11Cl2NOS |
CAS No. | 75450-34-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/mL (200.48 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0843 mL | 15.4216 mL | 30.8433 mL | 77.1081 mL |
5 mM | 0.6169 mL | 3.0843 mL | 6.1687 mL | 15.4216 mL | |
10 mM | 0.3084 mL | 1.5422 mL | 3.0843 mL | 7.7108 mL | |
20 mM | 0.1542 mL | 0.7711 mL | 1.5422 mL | 3.8554 mL | |
50 mM | 0.0617 mL | 0.3084 mL | 0.6169 mL | 1.5422 mL | |
100 mM | 0.0308 mL | 0.1542 mL | 0.3084 mL | 0.7711 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CGP37157 75450-34-9 Membrane transporter/Ion channel Na+/Ca2+ Exchanger CGP 37157 Inhibitor CGP-37157 inhibit 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one inhibitor