keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) 是基于 VH032 的 VHL 配体,可用于募集 von Hippel-Lindau (VHL) 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 269 | 现货 | ||
100 mg | ¥ 415 | 现货 | ||
500 mg | ¥ 1,550 | 现货 | ||
1 g | ¥ 2,280 | 现货 |
产品描述 | (S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). |
体外活性 | Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used |
别名 | VHL Ligand 1 hydrochloride, ULM-1, Protein degrader 1 hydrochloride |
分子量 | 467.03 |
分子式 | C22H31ClN4O3S |
CAS No. | 1448189-80-7 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1412 mL | 10.706 mL | 21.4119 mL | 53.5298 mL |
5 mM | 0.4282 mL | 2.1412 mL | 4.2824 mL | 10.706 mL | |
10 mM | 0.2141 mL | 1.0706 mL | 2.1412 mL | 5.353 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(S,R,S)-AHPC hydrochloride 1448189-80-7 Others PROTAC Ligand for E3 Ligase (S,R,S) AHPC hydrochloride VHL Ligand 1 Hydrochloride VH032-NH2 (S,R,S)AHPC hydrochloride inhibit (S,R,S)-AHPC VHL Ligand 1 hydrochloride VHL ligand 1 ULM-1 Ligands for E3 Ligase Protein degrader 1 Hydrochloride VHL ligand-1 ULM1 E3 ligase-recruiting Moiety VHL ligand1 ULM 1 Inhibitor AHPC Hydrochloride Protein degrader 1 hydrochloride inhibitor