Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HP-β-CD (HP-β-CD) 是一种药物递送载体,可提高稳定性和利用度。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 326 | 现货 | ||
1 g | ¥ 395 | 现货 | ||
5 g | ¥ 729 | 现货 | ||
10 g | ¥ 915 | 现货 |
产品描述 | HP-β-CD (HP-β-CD) is a widely used drug delivery vehicle to improve stability and bioavailability. |
体外活性 | Cell treatment with (2-hydroxypropyl)-β-cyclodextrin can activate the activation of the transcription factor EB (the main regulator of lysosomal function and autophagy) and enhance the cell's autophagy clearance ability[1]. HP-β-CD treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for HP-β-CD after 72 hours exposure are in the range of 3.86–10.09 mM. HP-β-CD also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by HP-β-CD[2]. |
体内活性 | 腹腔注射HP-β-CD能显著提高白血病小鼠模型的存活率。将HP-β-CD系统性给药于小鼠,未观察到明显不良反应[2]。 |
别名 | 羟丙基-β-环糊精, 羟丙基-BETA-环糊精, Hydroxypropyl-β-cyclodextrin, Hydroxypropyl betadex |
分子量 | 1541.5 |
分子式 | C63H112O42 |
CAS No. | 128446-35-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (29.19 mM)
H2O: 50 mg/mL, Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.6487 mL | 3.2436 mL | 6.4872 mL | 16.218 mL |
5 mM | 0.1297 mL | 0.6487 mL | 1.2974 mL | 3.2436 mL | |
10 mM | 0.0649 mL | 0.3244 mL | 0.6487 mL | 1.6218 mL | |
20 mM | 0.0324 mL | 0.1622 mL | 0.3244 mL | 0.8109 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
HP-β-CD 128446-35-5 Others (2Hydroxypropyl)βcyclodextrin 羟丙基-β-环糊精 羟丙基-BETA-环糊精 Hydroxypropyl-β-cyclodextrin HP-b-CD HP-beta-CD (2 Hydroxypropyl) β cyclodextrin Hydroxypropyl betadex Inhibitor Hydroxypropyl-beta-cyclodextrin inhibit Hydroxypropyl-b-cyclodextrin inhibitor