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Sodium benzoate

产品编号 T8124 CAS 532-32-1

别名: Benzoic acid sodium salt, 苯甲酸钠

Sodium benzoate (Benzoic acid sodium salt) 是一种 D-氨基酸氧化酶抑制剂。它是一种食品防腐剂。

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Sodium benzoate, CAS 532-32-1

规格	价格/CNY		货期	数量
500 mg	￥ 163		现货
1 mL * 10 mM (in DMSO)	￥ 99		现货

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其他形式的 Sodium benzoate:

选择批次

纯度: 98%

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Sodium benzoate (Benzoic acid sodium salt) is a D-Amino Acid Oxidase Inhibitor.Sodium Benzoate is a Food Preservative.
体外活性	At 24- and 48-hour. incubation time, sodium benzoate concentrations of 1.0, 1.5, and 2.0 mg/mL increased micronucleus formation when comparing with the control group (P < 0.05). At 24- and 48-hour. incubation time, sodium benzoate concentrations of 2.0 mg/mL increased chromosome break when comparing with the control group (P < 0.05). Sodium benzoate did not cause Ala40Thr (GCG→ACG) in superoxide dismutase gene. Sodium benzoate had the mutagenic and cytotoxic toxicity in lymphocytes caused by micronucleus formation and chromosome break[1].
体内活性	Sodium benzoate (NaB)?-treated rats spent less time in the open arm and had fewer entrances to the open arms in comparison with the control group (p<0.04). Also, the performance of the NaB-treated rats in fixed and accelerating speed rotarods was impaired, and the riding time (endurance) was lower than the control group (p<0.01)[2].
动物实验	The study was carried out between July and September 2012 in the Laboratory Animal Center of Shiraz University of Medical Sciences, Shiraz, Iran. The rats were divided into 2 groups receiving distilled water and sodium benzoate (NaB)? (200mg/kg/day). All the animals received daily gavages for 4 weeks. At the end of the fourth week, anxiety, and motor function were assessed in elevated plus maze and rotarod test[2]

别名	Benzoic acid sodium salt, 苯甲酸钠
分子量	144.1
分子式	C7H5NaO2
CAS No.	532-32-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 3.85 mg/mL (26.69 mM), Sonication is recommended.

H2O: 28 mg/mL (194.31 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO / H2O	1 mM	6.9396 mL	34.6981 mL	69.3963 mL	173.4906 mL
	5 mM	1.3879 mL	6.9396 mL	13.8793 mL	34.6981 mL
	10 mM	0.694 mL	3.4698 mL	6.9396 mL	17.3491 mL
	20 mM	0.347 mL	1.7349 mL	3.4698 mL	8.6745 mL
H2O	50 mM	0.1388 mL	0.694 mL	1.3879 mL	3.4698 mL
H2O	100 mM	0.0694 mL	0.347 mL	0.694 mL	1.7349 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Malinee P . Effect of Sodium Benzoate Preservative on Micronucleus Induction, Chromosome Break, and Ala40Thr Superoxide Dismutase Gene Mutation in Lymphocytes[J]. Biomed Research International, 2015, 2015:1-5. 2. Noorafshan A , Erfanizadeh M , Karbalaydoust S . Sodium benzoate, a food preservative, induces anxiety and motor impairment in rats.[J]. Neurosciences, 2014, 19(19):24-28. 3. Lin C H , Lin C H , Chang Y C , et al. Sodium Benzoate, a D-amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial[J]. Biological Psychiatry, 2017:S0006322317322977.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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