Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lagociclovir (MIV-210) 是一种核苷类似物,是一种可用治疗 HBV82的抗病毒化合物,可抑制野生型乙型肝炎病毒 (HBV) 在永久表达 HBV 的人肝癌细胞系中的复制。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,200 | 现货 | ||
5 mg | ¥ 5,350 | 现货 | ||
10 mg | ¥ 7,530 | 现货 | ||
25 mg | ¥ 10,900 | 现货 | ||
50 mg | ¥ 14,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,910 | 现货 |
产品描述 | Lagociclovir (MIV-210), a nucleoside analogue, is an antiviral compound available for the treatment of HBV82 that inhibits the replication of wild-type hepatitis B virus (HBV) in human hepatocellular carcinoma cell lines that permanently express HBV. |
靶点活性 | HBV (3TC-R):8 μM, PMEA-R (HBV):13 μM, HBV (WT):9 μM, HBV (3TC+PMEA-R):15 μM |
体外活性 |
Lagociclovir (FLG) (6 days) exhibited inhibitory activity against 3TC-R HBV, wt HBV, PMEA-R HBV and 3TC+PMEA-R HBV in transiently transfected Huh7 cells with IC50s of 8 ± 3.8, 9 ± 2.5, 13 ± 3.4 and 15 ± 6.8 μM, respectively [1]. Lagociclovir (0-100 μM; 6 days) inhibits the replication of HBV wild-type and drug-resistant mutants in transiently transfected Huh7 cells.[2] |
体内活性 | Anti-HBV compound Oral administration of MIV-210 (20 or 60 mg/kg; body weight/day) induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period.[1] |
别名 | MIV-210 |
分子量 | 269.23 |
分子式 | C10H12FN5O3 |
CAS No. | 92562-88-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (92.86 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.7143 mL | 18.5715 mL | 37.143 mL | 92.8574 mL |
5 mM | 0.7429 mL | 3.7143 mL | 7.4286 mL | 18.5715 mL | |
10 mM | 0.3714 mL | 1.8571 mL | 3.7143 mL | 9.2857 mL | |
20 mM | 0.1857 mL | 0.9286 mL | 1.8571 mL | 4.6429 mL | |
50 mM | 0.0743 mL | 0.3714 mL | 0.7429 mL | 1.8571 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lagociclovir 92562-88-4 Microbiology/Virology HBV MIV210 MIV-210 MIV 210 Inhibitor inhibitor inhibit