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Arg-Gly-Asp-Ser

产品编号 T10366 CAS 91037-65-9

别名: Fibronectin tetrapeptide, RGDS peptide

Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, MMP-9, and iNOS. 在相同实验条件下，摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性，但盐形式 Arg-Gly-Asp-Ser acetate 的水溶性和稳定性通常比游离态更好。

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Arg-Gly-Asp-Ser, CAS 91037-65-9

规格	价格/CNY		货期	数量
2 mg	￥ 188		5日内发货
5 mg	￥ 286		5日内发货

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Arg-Gly-Asp-Ser 的其他形式现货产品:

Arg-Gly-Asp-Ser acetate

其他形式的 Arg-Gly-Asp-Ser:

Arg-Gly-Asp-Ser acetate
现货
Arg-Gly-Asp-Ser (TFA)(91037-65-9,free)
询价

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, MMP-9, and iNOS.
体外活性	The Arg-Gly-Asp-Ser-modified surface causes up-regulation of αvβ3 integrin. Attachment to the Arg-Gly-Asp-Ser-treated membrane completely abolishes apoptosis induced by staurosporine, the Ca2+·Pi ion pair, and sodium nitroprusside. Arg-Gly-Asp-Ser-dependent resistance to apoptosis is eliminated, when the activity of the phosphatidylinositol 3-kinase pathway is inhibited [1]. Arg-Gly-Asp-Ser interacts with survivin, as well as with procaspase-3, -8 and -9. Arg-Gly-Asp-Ser-peptide binding to survivin is found to be specific, at high affinity (Kd: 27.5 μM) and locates at the survivin C-terminus [4].
体内活性	Arg-Gly-Asp-Ser (2.5 or 5 mg/kg, 1 h before LPS) significantly inhibits LPS-induced MMP-9 activity in BAL fluid 4 h post-LPS. Arg-Gly-Asp-Ser (1, 2.5, or 5 mg/kg, i.p.) administers 1 h before LPS inhibited LPS-induced increases in TNF-α and MIP-2 levels in BAL fluid at 4 h post-LPS [2]. Arg-Gly-Asp-Ser peptide significantly reduces TNF-α and macrophage inflammatory protein (MIP)-2 production and decreases myeloperoxidase (MPO) and NF-κB activity [3].

别名	Fibronectin tetrapeptide, RGDS peptide
分子量	433.42
分子式	C15H27N7O8
CAS No.	91037-65-9

存储

keep away from moisture　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 55 mg/mL (126.90 mM)

H2O: 25 mg/mL (57.68 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO / H2O	1 mM	2.3072 mL	11.5362 mL	23.0723 mL	57.6808 mL
	5 mM	0.4614 mL	2.3072 mL	4.6145 mL	11.5362 mL
	10 mM	0.2307 mL	1.1536 mL	2.3072 mL	5.7681 mL
	20 mM	0.1154 mL	0.5768 mL	1.1536 mL	2.884 mL
	50 mM	0.0461 mL	0.2307 mL	0.4614 mL	1.1536 mL
DMSO	100 mM	0.0231 mL	0.1154 mL	0.2307 mL	0.5768 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Grigoriou V, et al. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J Biol Chem. 2005 Jan 21;280(3):1733-9. 2. Moon C, et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res. 2009 Mar 9;10:18. 3. Yin X, et al. Synthetic RGDS peptide attenuated lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure in mice. J Gastroenterol Hepatol. 2014 Jun;29(6):1308-15. 4. Aguzzi MS, et al. Intracellular targets of RGDS peptide in melanoma cells. Mol Cancer. 2010 Apr 22;9:84.

文献引用

1. Sun B, Wu H, Lu J, et al. Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta. Journal of Orthopaedic Translation. 2023, 38: 175-189.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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