keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIP-135 是一个高效、选择性的,ATP 竞争性的 GSK-3 抑制剂,对 GSK-3α 和 GSK-3β 作用的 IC50 值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 526 | 现货 | ||
2 mg | ¥ 758 | 现货 | ||
5 mg | ¥ 1,220 | 现货 | ||
10 mg | ¥ 1,970 | 现货 | ||
25 mg | ¥ 3,890 | 现货 | ||
50 mg | ¥ 5,570 | 现货 | ||
100 mg | ¥ 7,780 | 现货 | ||
500 mg | ¥ 15,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,370 | 现货 |
产品描述 | BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1]. |
靶点活性 | GSK-3α:16 nM, GSK-3β:21 nM |
体外活性 | BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress[1]. BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations[1]. |
体内活性 | BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy. And it does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1]. |
分子量 | 421.24 |
分子式 | C21H13BrN2O3 |
CAS No. | 941575-71-9 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 56.7 mg/mL (134.6 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3739 mL | 11.8697 mL | 23.7394 mL | 59.3486 mL |
5 mM | 0.4748 mL | 2.3739 mL | 4.7479 mL | 11.8697 mL | |
10 mM | 0.2374 mL | 1.187 mL | 2.3739 mL | 5.9349 mL | |
20 mM | 0.1187 mL | 0.5935 mL | 1.187 mL | 2.9674 mL | |
50 mM | 0.0475 mL | 0.2374 mL | 0.4748 mL | 1.187 mL | |
100 mM | 0.0237 mL | 0.1187 mL | 0.2374 mL | 0.5935 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BIP-135 941575-71-9 PI3K/Akt/mTOR signaling Stem Cells GSK-3 BIP 135 BIP135 Inhibitor inhibitor inhibit