keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(Arg)9 (Nona-L-arginine;Peptide R9) is a cell-penetrating peptide,and exhibits neuroprotective activity(IC50 of 0.78 μM, in the glutamic acid model).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 1,995 | 5日内发货 |
(Arg)9 的其他形式现货产品:
产品描述 | (Arg)9 (Nona-L-arginine;Peptide R9) is a cell-penetrating peptide,and exhibits neuroprotective activity(IC50 of 0.78 μM, in the glutamic acid model). |
靶点活性 | Neuroprotection:0.78 μM |
体外活性 | Poly-arginine (e.g. (Arg)9) with cell-penetrating properties are neuroprotective. (Arg)9 provides significant neuroprotection in a dose–response manner following glutamic acid exposure with IC50 of 0.78 μM. Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model with IC50 of 0.81 μM. (Arg)9 also shows neuroprotection following in vitro ischemia with IC50 of 6 μM[1]. |
体内活性 | In rat stroke models, (Arg)9) (D-isoform) is neuroprotective. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect[2]. (Arg) 9) (D-isoform) was administered intravenously at a dose of 1000 nmol/kg 30 minutes after permanent middle cerebral artery occlusion (MCAO) [3]. |
别名 | Peptide R9, Nona-L-arginine |
分子量 | 1423.69 |
分子式 | C54H110N36O10 |
CAS No. | 143413-47-2 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(Arg)9 143413-47-2 Others Peptide R9 Nona-L-arginine Inhibitor inhibitor inhibit