Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS023 is a type I PRMT inhibitor (IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 776 | 待询 | ||
5 mg | ¥ 3,409 | 待询 | ||
10 mg | ¥ 6,018 | 待询 | ||
25 mg | ¥ 13,149 | 待询 |
MS023 (hydrochloride) (1831110-54-3 free base) 的其他形式现货产品:
产品描述 | MS023 is a type I PRMT inhibitor (IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively). |
体外活性 | MS023 was identified to have high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but was inactive against type II and type III PRMTs, protein lysine methyltransferases as well as DNA methyltransferases. The crystal structure of PRMT6 with MS023 indicated that MS023 bound to the substrate-binding site. Moreover, MS023 could potentially decrease the cellular levels of histone arginine asymmetric dimethylation. In cells, MS023 also ould reduce the levels of arginine asymmetric dimethylation and increase levels of arginine monomethylation and symmetric dimethylation. Therefore, MS023 is a useful chemical tool for testing the role of type I PRMTs in health and disease [1]. |
别名 | MS023 (hydrochloride) |
分子量 | 396.8 |
分子式 | C17H25N3O·3HCl |
CAS No. | T23030 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: ≤30mg/mL
DMSO: 30mg/ml
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MS023 (hydrochloride) (1831110-54-3 free base) T23030 Others 1831110-54-3 1831110-54-3 free base MS023 MS023 (hydrochloride) (1831110 54 3 free base) MS-023 MS023 (hydrochloride) (1831110543 free base) MS-023 (hydrochloride) (1831110-54-3 free base) MS023 (hydrochloride) MS 023 Inhibitor inhibitor inhibit