Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,820 | 5日内发货 | ||
5 mg | ¥ 3,320 | 5日内发货 | ||
25 mg | ¥ 11,600 | 8-10周 | ||
50 mg | ¥ 15,100 | 8-10周 | ||
100 mg | ¥ 21,500 | 8-10周 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,970 | 5日内发货 |
Celgosivir hydrochloride 的其他形式现货产品:
产品描述 | Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM). |
靶点活性 | α-glucosidase I:1.27 μM |
体外活性 | Celgosivir is more effective (IC50: 20 μM) than the parent molecule (IC50: 254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Celgosivir exhibits potent antiviral activity against HIV-1 (IC50: 2.0 μM) [1]. BVDV is a closely related virus of hepatitis C virus (HCV). Celgosivir inhibits BVDV with IC50 values of 16 and 47 μM in plaque assay and cytopathic effect assay, respectively [2]. Celgosivir inhibits DENV2 replication with an EC50 of 0.2 μM. The EC50 values against DENV1, 3, and 4 are less than 0.7 μM [3]. |
体内活性 | During primary infection with a mouse-adapted DENV strain S221, mice show increased viremia on day 3, yet 80% survived day 10 with a virus completely cleared by day 8 [3]. Celgosivir (50 mg/kg, BID for 5 days) fully protects AG129 mice from lethal infection with a mouse-adapted dengue virus and is effective even after 48 h delayed treatment. The protection by celgosivir is dose- and schedule-dependent and that a twice-a-day regimen of 50, 25, or 10 mg/kg is more protective than a single daily dose of 100 mg/kg. Pharmacokinetics studies of celgosivir in mice show that it rapidly metabolizes to castanospermine [4]. |
别名 | MX3253 hydrochloride, MBI 3253 hydrochloride, MDL 28574 hydrochloride |
分子量 | 295.76 |
分子式 | C12H22ClNO5 |
CAS No. | 141117-12-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL (338.11 mM)
DMSO: 100 mg/mL (338.11 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 3.3811 mL | 16.9056 mL | 33.8112 mL | 84.528 mL |
5 mM | 0.6762 mL | 3.3811 mL | 6.7622 mL | 16.9056 mL | |
10 mM | 0.3381 mL | 1.6906 mL | 3.3811 mL | 8.4528 mL | |
20 mM | 0.1691 mL | 0.8453 mL | 1.6906 mL | 4.2264 mL | |
50 mM | 0.0676 mL | 0.3381 mL | 0.6762 mL | 1.6906 mL | |
100 mM | 0.0338 mL | 0.1691 mL | 0.3381 mL | 0.8453 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Celgosivir hydrochloride 141117-12-6 Others MX3253 hydrochloride MBI-3253 Hydrochloride MX-3253 Hydrochloride MX3253 Hydrochloride MDL 28574 Hydrochloride MDL-28574 Hydrochloride MX 3253 Hydrochloride MBI 3253 Hydrochloride MBI 3253 hydrochloride MDL 28574 hydrochloride Celgosivir Hydrochloride MBI3253 Hydrochloride MDL28574 Hydrochloride Inhibitor inhibitor inhibit