Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS 193885 是一种选择性和竞争性神经肽 Y(1) 受体拮抗剂,亲和力为 3.3 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 5,880 | 4-5周 | ||
50 mg | ¥ 23,500 | 4-5周 |
BMS 193885 的其他形式现货产品:
产品描述 | BMS 193885 is a selective and competitive neuropeptide Y(1) receptor antagonist with affinity of 3.3 nM. |
体外活性 | BMS 193885 increases the Kd of [(125)I]PeptideYY from 0.35 nM to 0.65 nM without changing the Bmax (0.16 pmol/mg of protein) in SK-N-MC cells that endogenously express the neuropeptide Y(1) receptor[1]. BMS 193885 is a full antagonist with an apparent Kb of 4.5 nM measured by reversal of forskolin-stimulated inhibition of cAMP production by neuropeptide Y[1]. |
体内活性 | BMS 193885 (10 mg/kg; i.p.) reduces one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption. Chronic administration of BMS 193885 (10 mg/kg) i.p. for 44 days significantly reduces food intake and the rate of body weight gain compared to vehicle treated control without developing tolerance or affecting water intake[1]. |
别名 | BMS193885 |
分子量 | 680.79 |
分子式 | C36H48N4O9 |
CAS No. | 679839-66-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: <13.62mg/ml
DMSO: 63mg/mL (92.5mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.4689 mL | 7.3444 mL | 14.6888 mL | 36.722 mL |
5 mM | 0.2938 mL | 1.4689 mL | 2.9378 mL | 7.3444 mL | |
10 mM | 0.1469 mL | 0.7344 mL | 1.4689 mL | 3.6722 mL | |
20 mM | 0.0734 mL | 0.3672 mL | 0.7344 mL | 1.8361 mL | |
50 mM | 0.0294 mL | 0.1469 mL | 0.2938 mL | 0.7344 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BMS 193885 679839-66-8 GPCR/G Protein Neuroscience Neuropeptide Y Receptor BMS193885 BMS-193885 Inhibitor inhibitor inhibit