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SHP-2 Protein, Mouse, Recombinant (His)
还可以产品编号 TMPY-03125
别名 Syp, SH-PTP3, SH-PTP2, SHP-2, Shp2, SAP-2, PTP2C, PTP1D, protein tyrosine phosphatase, non-receptor type 11, AW536184, 2700084A17Rik
SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulation of its RhoA binding activity.
SHP-2 Protein, Mouse, Recombinant (His)
还可以产品编号 TMPY-03125 别名 Syp, SH-PTP3, SH-PTP2, SHP-2, Shp2, SAP-2, PTP2C, PTP1D, protein tyrosine phosphatase, non-receptor type 11, AW536184, 2700084A17Rik
SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulation of its RhoA binding activity.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 200 μg | ¥ 5,750 | 5日内发货 |
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| 产品描述 | SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulation of its RhoA binding activity. |
| 别名 | Syp, SH-PTP3, SH-PTP2, SHP-2, Shp2, SAP-2, PTP2C, PTP1D, protein tyrosine phosphatase, non-receptor type 11, AW536184, 2700084A17Rik |
| 分子量 | 69.5 kDa (predicted); 65 kDa (reducing condition, due to glycosylation) |
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| 存储 | Shipping with blue ice. |
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