购物车
- 全部删除
您的购物车当前为空
Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 2
还可以
产品编号 TMAC-02829
别名 p-NFKB1 (Ser337), p-NFKB1 (S337), NFKB1 (p-Ser337), NFKB1 (p-S337)
Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-NFKB1 (Ser337)。Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 可用于 WB,IHC,IF。
Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 2
Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 2
还可以产品编号 TMAC-02829 别名 p-NFKB1 (Ser337), p-NFKB1 (S337), NFKB1 (p-Ser337), NFKB1 (p-S337)
Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-NFKB1 (Ser337)。Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 可用于 WB,IHC,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,245 | 5日内发货 |
大包装 & 定制
加入购物车
TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody is a Rabbit antibody targeting Phospho-NFKB1 (Ser337). Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody can be used in WB,IHC,IF. |
| 别名 | p-NFKB1 (Ser337), p-NFKB1 (S337), NFKB1 (p-Ser337), NFKB1 (p-S337) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Immunofluorescence staining of methanol-fixed HeLa cells using NF-κB p105/p50 (phospho-Ser337) antibody (TMAC-02829, Red). 2. Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using NF-κB p105/p50 (phospho-Ser337) antibody (TMAC-02829). 3. Western blot analysis of extract from HeLa cells, using NF-κB p105/p50 (phospho-Ser337) antibody (TMAC-02829, Lane 1 and 2). 4. Western blot analysis of extracts from Hela cells, treated with Noc or calf intestinal phosphatase (CIP), using NFκB-p105/p50(Phospho-Ser337) Antibody TMAC-02829. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. Beg A.A., Baldwin A.S. Jr.Oncogene 9:1487-1492(1994) Guizani-Tabbane L., Ben-Aissa K., Belghith M., Sassi A., Dellagi K.Infect. Immun. 72:2582-2589(2004) Beinke S., Robinson M.J., Hugunin M., Ley S.C.Mol. Cell. Biol. 24:9658-9667(2004) |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of serine 337(R-K-S(p)-D-L) derived from Human NFκB-p105/p50 |
| 抗原种属 | human |
| Uniprot ID |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
SCI 文献
关键词
评论列表
预览
Related Tags: buy Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 2 | purchase Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 2 | Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 2 cost | order Anti-Phospho-NFKB1 (Ser337) Polyclonal Antibody 2
嗨！有任何问题？点我咨询
评论内容