购物车
- 全部删除
您的购物车当前为空
Anti-ITCH/AIP4 Antibody-FITC (6J974)
还可以
产品编号 TMAY-01671F
别名 NAPP1, ITCH, AIP4, AIP 4, AIF4, ADMFD
Anti-ITCH/AIP4 Antibody-FITC (6J974) 是一种 FITC-conjugated Mouse 抗体，靶向 ITCH/AIP4。Anti-ITCH/AIP4 Antibody-FITC (6J974) 可用于 FCM。
Anti-ITCH/AIP4 Antibody-FITC (6J974)
331 Anti-ITCH/AIP4 Antibody-FITC (6J974)
还可以产品编号 TMAY-01671F 别名 NAPP1, ITCH, AIP4, AIP 4, AIF4, ADMFD
Anti-ITCH/AIP4 Antibody-FITC (6J974) 是一种 FITC-conjugated Mouse 抗体，靶向 ITCH/AIP4。Anti-ITCH/AIP4 Antibody-FITC (6J974) 可用于 FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 T | ¥ 880 | 5日内发货 | |
| 100 T | ¥ 1,780 | 5日内发货 |
大包装 & 定制
加入购物车
TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-ITCH/AIP4 Antibody-FITC (6J974) is a FITC-conjugated Mouse antibody targeting ITCH/AIP4. Anti-ITCH/AIP4 Antibody-FITC (6J974) can be used in FCM. |
| 别名 | NAPP1, ITCH, AIP4, AIP 4, AIF4, ADMFD |
| Ig Type | Mouse IgG1 |
| 克隆号 | 6J974 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human ITCH expression in HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with FITC Mouse anti-ITCH. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ITCH / AIP4 (rh ITCH / AIP4; NP_113671.3; Arg 526-Glu 903) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and contains four WW domains. ITCH acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. ITCH is involved in the control of inflammatory signaling pathways. It is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1, and RNF11, that ensures the transient nature of inflammatory signaling pathways. ITCH promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Defects in ITCH are the cause of the syndromic multisystem autoimmune disease (SMAD) which is characterized by organomegaly, failure to thrive, developmental delay, dysmorphic features, and autoimmune inflammatory cell infiltration of the lungs, liver, and gut. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Protein: Human ITCH / AIP4 protein |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
SCI 文献
评论列表
预览
Related Tags: buy Anti-ITCH/AIP4 Antibody-FITC (6J974) | purchase Anti-ITCH/AIP4 Antibody-FITC (6J974) | Anti-ITCH/AIP4 Antibody-FITC (6J974) cost | order Anti-ITCH/AIP4 Antibody-FITC (6J974)
嗨！有任何问题？点我咨询
评论内容