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Anti-AURKA Polyclonal Antibody
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产品编号 TMAB-00173
别名 STK6, STK15, Serine/threonine-protein kinase Ayk1, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase 15, Ipl1- and aurora-related kinase 1, IAK1, BTAK, Breast tumor-amplified kinase, AYK1, Aurora/IPL1-related kinase 1 (ARK-1;Aurora-related kinase 1), Aurora kinase A, Aurora 2, AURKA, AURA, ARK1, AIRK1, AIK
Anti-AURKA Polyclonal Antibody 是一种 Rabbit 抗体，靶向 AURKA。Anti-AURKA Polyclonal Antibody 可用于 WB。
Anti-AURKA Polyclonal Antibody
Anti-AURKA Polyclonal Antibody
还可以产品编号 TMAB-00173 别名 STK6, STK15, Serine/threonine-protein kinase Ayk1, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase 15, Ipl1- and aurora-related kinase 1, IAK1, BTAK, Breast tumor-amplified kinase, AYK1, Aurora/IPL1-related kinase 1 (ARK-1;Aurora-related kinase 1), Aurora kinase A, Aurora 2, AURKA, AURA, ARK1, AIRK1, AIK
Anti-AURKA Polyclonal Antibody 是一种 Rabbit 抗体，靶向 AURKA。Anti-AURKA Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,165 | 5日内发货 | |
| 100 μL | ¥ 1,960 | 5日内发货 | |
| 200 μL | ¥ 2,780 | 5日内发货 |
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| 产品描述 | Anti-AURKA Polyclonal Antibody is a Rabbit antibody targeting AURKA. Anti-AURKA Polyclonal Antibody can be used in WB. |
| 别名 | STK6, STK15, Serine/threonine-protein kinase Ayk1, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase 15, Ipl1- and aurora-related kinase 1, IAK1, BTAK, Breast tumor-amplified kinase, AYK1, Aurora/IPL1-related kinase 1 (ARK-1;Aurora-related kinase 1), Aurora kinase A, Aurora 2, AURKA, AURA, ARK1, AIRK1, AIK |
| Ig Type | IgG |
| 交叉反应 | Mouse |
| 验证活性 | Sample: Lane 1: Large intestine (Mouse) Lysate at 40 μg Lane 2: Lung (Mouse) Lysate at 40 μg Lane 3: Kidney (Mouse) Lysate at 40 μg Lane 4: NIH/3T3 (Mouse) Cell Lysate at 30 μg Primary: Anti-Aurora A (TMAB-00173) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 48 kDa Observed band size: 48 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase. Moves to the midbody during both telophase and cytokinesis. Associates with both the pericentriolar material (PCM) and centrioles. |
| 组织特异性 | Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10), behaves as a chromosomal passenger protein, and may regulate several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis. It localizes to the inner centromere region from prophase to anaphase. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase. |
| 免疫原 | KLH conjugated synthetic peptide: human Auroa A |
| 抗原种属 | Human |
| 基因名称 | AURKA |
| 基因ID | |
| 蛋白名称 | Aurora kinase A |
| Uniprot ID | |
| 研究领域 | Cell division,Tumor biomarkers,Spindle,Aurora |
| 功能 | Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. |
| 分子量 | Theoretical: 48 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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