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L-Homocysteine thiolactone hydrochloride

产品编号 T19393 CAS 31828-68-9

L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of homocysteine,It prevents translational incorporation of homocysteine into proteins.

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L-Homocysteine thiolactone hydrochloride Chemical Structure

L-Homocysteine thiolactone hydrochloride, CAS 31828-68-9

规格	价格/CNY	货期
2 mg	￥ 167	5日内发货
5 mg	￥ 268	5日内发货
10 mg	￥ 449	5日内发货

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L-Homocysteine thiolactone hydrochloride 的其他形式现货产品:

DL-Homocysteine thiolactone hydrochloride

其他形式的 L-Homocysteine thiolactone hydrochloride:

DL-Homocysteine thiolactone hydrochloride
现货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of homocysteine,It prevents translational incorporation of homocysteine into proteins.
体外活性	Homocysteine thiolactone induces cell death and features of apoptosis including increased phosphotidylserine exposure on the membrane surface, increased apoptotic cells with hypoploid DNA contents, and internucleosomal DNA fragmentation in HL-60 cells. Homocysteine thiolactone is cytotoxic and capable of promoting cell death, as measured by caspase-3 activation and DNA fragmentation. HcyT strongly activates IL-8 release.In all cell types, from bacterial to human, homocysteine is metabolized to homocysteine thiolactone by methionyl-tRNA synthetase.?Elevated levels of homocysteine are an independent risk factor for cardiovascular disease in humans.?Homocysteine can be harmful to human cells because of its metabolic conversion to homocysteine thiolactone, a reactive thioester.?This conversion occurs in all human cell types, including endothelial cells.
体内活性	Homocysteine thiolactone induces two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. The grade of seizures is dose dependent.?Homocysteine thiolactone is toxic, induces epileptic seizures in rodents, and has been implicated in Alzheimer's disease.

分子量	153.63
分子式	C4H8ClNOS
CAS No.	31828-68-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 23 mg/mL (149.71 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
H2O	1 mM	6.5091 mL	32.5457 mL	65.0915 mL	162.7286 mL
	5 mM	1.3018 mL	6.5091 mL	13.0183 mL	32.5457 mL
	10 mM	0.6509 mL	3.2546 mL	6.5091 mL	16.2729 mL
	20 mM	0.3255 mL	1.6273 mL	3.2546 mL	8.1364 mL
	50 mM	0.1302 mL	0.6509 mL	1.3018 mL	3.2546 mL
	100 mM	0.0651 mL	0.3255 mL	0.6509 mL	1.6273 mL

计算器

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参考文献

1. Jakubowski H, et al. Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J Nutr. 2000 Feb;130(2S Suppl):377S-381S. 2. Huang RF, et al. Homocysteine thiolactone induces apoptotic DNA damage mediated by increased intracellularhydrogen peroxide and caspase 3 activation in HL-60 cells. Life Sci. 2001 May 11;68(25):2799-811. 3. Kerkeni M, et al. Comparative study on in vitro effects of homocysteine thiolactone and homocysteine on HUVECcells: evidence for a stronger proapoptotic and proinflammative homocysteine thiolactone. Mol Cell Biochem. 2006 Oct;291(1-2):119-26. 4. Borowczyk K, et al. Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1. J Alzheimers Dis. 2012;30(2):225-31. 5. Stanojlović O, et al. Two types of seizures in homocysteine thiolactone-treated adult rats, behavioral and electroencephalographic study. Cell Mol Neurobiol. 2009 May;29(3):329-39.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

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动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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