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Anti-Phospho-Lck (Tyr394) Polyclonal Antibody
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产品编号 TMAC-02385
别名 p-Lck (Y394), p-Lck (Tyr394), Lck (p-Y394), Lck (p-Tyr394)
Anti-Phospho-Lck (Tyr394) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Lck (Tyr394)。Anti-Phospho-Lck (Tyr394) Polyclonal Antibody 可用于 WB。
Anti-Phospho-Lck (Tyr394) Polyclonal Antibody
Anti-Phospho-Lck (Tyr394) Polyclonal Antibody
还可以产品编号 TMAC-02385 别名 p-Lck (Y394), p-Lck (Tyr394), Lck (p-Y394), Lck (p-Tyr394)
Anti-Phospho-Lck (Tyr394) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Lck (Tyr394)。Anti-Phospho-Lck (Tyr394) Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,235 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-Lck (Tyr394) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Lck (Tyr394). Anti-Phospho-Lck (Tyr394) Polyclonal Antibody can be used in WB. |
| 别名 | p-Lck (Y394), p-Lck (Tyr394), Lck (p-Y394), Lck (p-Tyr394) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of extracts from JK cells untreated or treated with starvation using Lck (Phospho-Tyr394) Antibody TMAC-02385. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature a beta TCR. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of tyrosine 394 (N-E-Y(p)-T-A) derived from Human Lck |
| 抗原种属 | human |
| Uniprot ID |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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