购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部生物活性储存和溶解信息计算器

Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 2

Rating icon 还可以
Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 2
产品编号 TMAC-02271
别名 p-JAK2 (Y221), p-JAK2 (Tyr221), JAK2 (p-Y221), JAK2 (p-Tyr221)

Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-JAK2 (Tyr221)。Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 可用于 IHC。

Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 2

Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 2

Rating icon 还可以
Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 2
产品编号 TMAC-02271 别名 p-JAK2 (Y221), p-JAK2 (Tyr221), JAK2 (p-Y221), JAK2 (p-Tyr221)

Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-JAK2 (Tyr221)。Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 可用于 IHC。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,235
5日内发货
大包装 & 定制
加入购物车
TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
联系我们获取更多批次信息
资源下载
产品操作手册

产品介绍

生物活性
产品描述
Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody is a Rabbit antibody targeting Phospho-JAK2 (Tyr221). Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody can be used in IHC.
别名p-JAK2 (Y221), p-JAK2 (Tyr221), JAK2 (p-Y221), JAK2 (p-Tyr221)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using JAK2 (phospho-Tyr221) antibody (TMAC-02271).
应用
IHC
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of tyrosine 221(Q-D-Y(p)-H-I)derived from Human JAK2
抗原种属
human
Uniprot ID
O60674
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器

关键词

pJAK2 (Y221)pJAK2 (Tyr221)JAK2 (pY221)JAK2 (pTyr221)JAK2 (phospho-Y221)JAK2 (phospho-Tyr221)

评论列表

4个月前
5.0
Rating icon 很棒

评论内容

233
Related Tags: buy Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 2 | purchase Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 2 | Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 2 cost | order Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody 2