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Anti-Insulin Receptor Antibody (5X84)
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产品编号 TMAC-02169
别名 Insulin Receptor, HHF5, CD220
Anti-Insulin Receptor Antibody (5X84) 是一种 Rabbit 抗体，靶向 Insulin Receptor。Anti-Insulin Receptor Antibody (5X84) 可用于 WB,ICC/IF。
Anti-Insulin Receptor Antibody (5X84)
Anti-Insulin Receptor Antibody (5X84)
还可以产品编号 TMAC-02169 别名 Insulin Receptor, HHF5, CD220
Anti-Insulin Receptor Antibody (5X84) 是一种 Rabbit 抗体，靶向 Insulin Receptor。Anti-Insulin Receptor Antibody (5X84) 可用于 WB,ICC/IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-Insulin Receptor Antibody (5X84) is a Rabbit antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody (5X84) can be used in WB,ICC/IF. |
| 别名 | Insulin Receptor, HHF5, CD220 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of Insulin Receptor on different lysates using anti-Insulin Receptor antibody at 1/1,000 dilution. Positive control: Lane 1: 293, Lane 2: MCF-7, Lane 3: Hela. 2. ICC staining Insulin Receptor in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining Insulin Receptor in LO2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining Insulin Receptor in RH-35 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining Insulin Receptor in PANC-1 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; ICC/IF: 1:100-500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular β subunit and an extracellular α subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. The human insulin receptor gene maps to chromosome 19p13.3-p13.2 and encodes a 1382 amino acid protein that cleaves to form α and β subunits. Type 1 diabetes is an auto-immune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells. Type 2 diabetes is a condition where cells become resistant to insulin action. |
| 偶联 | Unconjugated |
| 免疫原 | A synthesized peptide: within human Insulin receptor aa 930-970 |
| 抗原种属 | human |
| 基因ID | |
| Uniprot ID |
| 分子量 | Theoretical: 156 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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