NOS

Nitric oxide synthases(NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS).

Cat. No.	Product Name	CAS No.	Purity
TN4446	Longiferone B 化合物 TN4446	1639810-67-5	98%
TN4446	Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression.
TN4420	Latifolin 化合物 TN4420	10154-42-4	98%
TN4420	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
TN3744	Cyclomorusin 化合物 TN3744	62596-34-3	98%
TN3744	Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of s...
TN5019	Siegeskaurolic acid 化合物Siegeskaurolic acid	52645-97-3	98%
TN5019	Siegeskaurolic acid 是一种具有抗炎活性的天然产物。
TN1834	Kobusin 自旋七叶素	36150-23-9	98%
TN1834	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammat...
T11806	L-NIO dihydrochloride 化合物 T11806	159190-44-0	98%
T11806	L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats. L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide syntha...
T4S1616	Sanggenon D 桑根酮D	81422-93-7	98%
T4S1616	Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflamma...
TN4162	Goshonoside F5 化合物 TN4162	90851-28-8	98%
TN4162	Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN1562	Dehydromiltirone 去氢丹参新酮	116064-77-8	98%
TN1562	Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
T11518	GW274150 phosphate 化合物 T11518	438542-15-5	98%
T11518	GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and ra...
TN4648	Nepetoidin B 化合物Nepetoidin B	55486-06-1	98%
TN4648	Nepetoidin B 具有抗真菌、抗细菌和抗炎作用，它可以抑制 LPS 刺激的 NO 生成，可能是通过调节 RAW 264.7 细胞中由 MKP-5/NF-ÎºB 通路介导的 iNOS 。
T17056	Tetrahydrobiopterin 四氢生物蝶呤	17528-72-2	98%
T17056	Tetrahydrobiopterin (BH4) 是芳香族氨基酸羟化酶的辅因子, 也是一氧化氮合酶 (NOS) 的必需辅因子，可用于研究如高血压、高胆固醇血症、糖尿病等内皮功能障碍。
TN5264	Xanthoxyletin 化合物 TN5264	84-99-1	98%
TN5264	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
TN2641	15-Methoxypinusolidic acid 化合物 TN2641	769928-72-5	98%
TN2641	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN4291	Isofuranodiene 化合物 TN4291	57566-47-9	98%
TN4291	Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver dise...
TN4635	Neoechinulin A 化合物 TN4635	51551-29-2	98%
TN4635	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...
T2876	Flavone 黄酮	525-82-6	99.99%
T2876	Flavone (2-Phenyl-4-chromone) 是内源性代谢产物的一种。
TN1006	Tirucallol 表大戟二烯醇	514-46-5	99.98%
TN1006	Tirucallol 是一种四环三萜，分离自Euphorbia lacteal 乳胶。它能够抑制小鼠模型中的耳部水肿，并阻碍脂多糖刺激的巨噬细胞中亚硝酸盐的产生，具有局部消炎作用。
T5S0281	Tubuloside A 管花苷A	112516-05-9	99.93%
T5S0281	Tubuloside A 是一种苯乙醇苷，具有抗氧化活性和保肝活性。
T2S0843	Negletein 黄芩素-7-甲醚	29550-13-8	99.92%
T2S0843	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。