HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product Name	CAS No.	Purity
T5S0983	Absinthin 洋艾素	1362-42-1
T5S0983	Absinthin (Absynthin) 是结构独特的三萜类化合物，是艾草苦味高的原因。它是苦味受体hTAS2R46的激动剂，它利用 hTAS2R46 介导的受体特异性机制抑制组胺诱导的细胞内 Ca2+升高。
TN2186	Schisantherin D 五味子酯 D	64917-82-4	98%
TN2186	Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
T14208	AMD 3465 化合物 T14208	185991-24-6	98%
T14208	AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) i...
T16829	(S)-BI-1001 化合物 T16829	957889-73-5	98%
T16829	(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
T78737	NNRTIs-IN-3 化合物 NNRTIs-IN-3		98%
T78737	NNRTIs-IN-3（化合物8）作为一种HIV-1非核苷逆转录酶抑制剂，表现出较高的效力（EC50=0.01 µM）。
T78950	HIV-1 protease-IN-8 化合物 HIV-1 protease-IN-8	2925287-55-2	98%
T78950	HIV-1protease-IN-8（compound 34b）是一款高效的HIV-1蛋白酶抑制剂，其IC50为0.32 nM。该化合物对野生型HIV-1（HIV-1NL4-3）及耐药变体（HIV-1MDR）的IC50分别为0.29 μM与1.90 μM，表明其对这两种型别均展现出显著的抗病毒效果。
T79295	HIV-1 protease-IN-9 化合物 HIV-1 protease-IN-9	2925381-27-5	98%
T79295	HIV-1protease-IN-9 (compound 5b)为HIV-1蛋白酶抑制剂，具有0.028 nM的Ki值和66.8 nM的IC50，表现出显著的抗病毒活性。
T79536	HIV-1 protease-IN-11 化合物 HIV-1 protease-IN-11	2925287-54-1	98%
T79536	HIV-1protease-IN-11 (compound 34a) 为一抗HIV-1蛋白酶抑制剂，其IC50值为0.41 nM，并对抗耐药变异表现出显著活性。
T79537	HIV-1 protease-IN-12 化合物 HIV-1 protease-IN-12	2925287-59-6	98%
T79537	HIV-1protease-IN-12 (compound 35b)为HIV-1蛋白酶抑制剂，具有0.51 nM的IC50值，同时对HIV耐药变体也具有抑制作用。
T79953	Acetyl-binankadsurin A 化合物 Acetyl-binankadsurin A	77174-33-5	98%
T79953	Acetyl-binankadsurin A（化合物5）是从南五味子（Kadsura longipedunculata）中提取的一种木脂素。该化合物对HIV-1蛋白酶表现出较低的抑制活性，其半抑制浓度（IC50）超过100 μg/mL。
T80112	Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 化合物 Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2	130877-92-8	98%
T80112	Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 是一种用于检测HIV-1蛋白酶活性的荧光底物。
TN4347	Jacoumaric acid 化合物 TN4347	63303-42-4	98%
TN4347	Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor.
TN3567	Calanolide E 化合物 TN3567	142566-61-8	98%
TN3567	Calanolide E2 has anti-HIV activity.
TN4433	Licoarylcoumarin 化合物 TN4433	125709-31-1	98%
TN4433	Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE st...
TN5243	Vitexilactone 化合物 TN5243	61263-49-8	98%
TN5243	Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse trans...
T2S0605	Liquidambaric lactone 路路通内酯	185051-75-6	98%
T2S0605	Liquidambaric lactone 是一种分离自Euonymus grandiflorusWall 中的化合物。
TN1767	InteriotherinA 内南五味子酯A	181701-06-4	98%
TN1767	Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
TN1235	3,4,5-Tricaffeoylquinic acid 3,4,5-三咖啡酰奎宁酸	86632-03-3	98%
TN1235	3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like rece...
TN4820	Pre-schisanartanin B 化合物 TN4820	1033288-92-4	98%
TN4820	Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
TN5011	Shizukaol B 化合物 TN5011	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...