CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product Name	CAS No.	Purity
T79606	CAF-382 化合物 CAF-382		98%
T79606	CAF-382（compound B1）为SNS-032类似物，同时兼具CDKL5和泛CDK抑制功能，对GSK3α/β展现出较弱亲和性（>1.8 μM）及抑制效力。该化合物通过抑制CDKL5作用，进而阻止CDKL5 E2结构域发生磷酸化。
T79631	CDK9-IN-26 化合物 CDK9-IN-26		98%
T79631	CDK9-IN-26 (化合物1d) 为CDK9抑制剂，具有0.18 µM的IC50值。
T79640	ZNL-05-044 化合物 ZNL-05-044		98%
T79640	ZNL-05-044为CDK11抑制剂，在NanoBRET实验中展现对CDK11A与CDK11B的高度选择性，其IC50分别为0.23 μM及0.27 μM。该化合物诱导G2/M细胞周期阻滞，并对RNA剪接产生破坏作用。
T79648	CDK2-IN-19 化合物 CDK2-IN-19		98%
T79648	CDK2-IN-19 (Compound 32)为一种口服活性的选择性CDK2抑制剂（Ki：0.18 nM），在带OVCAR3肿瘤的小鼠模型中表现出显著的抗癌效果。
T79704	CDK9-IN-28 化合物 CDK9-IN-28		98%
T79704	CDK9-IN-28（化合物10）是一种高效CDK9抑制剂，可用作PROTAC合成中的靶蛋白配体，并在实体瘤中展现出显著的抗增殖能力。
T79862	Tacaciclib 化合物 Tacaciclib	2768774-66-7	98%
T79862	Tacaciclib为一CDK (cyclin-dependent kinases) 抑制剂，显示出抗肿瘤活性。
T79863	Tibremciclib 化合物 Tibremciclib	2397678-18-9	98%
T79863	Tibremciclib为CDK4抑制剂，展示出抗肿瘤活性。
T79881	CDK7-IN-25 化合物 CDK7-IN-25	2009209-60-1	98%
T79881	CDK7-IN-25 (CY-16-1)为一CDK-7抑制剂，具有极低的半抑制浓度(IC50<1nM)，主要用于癌症研究领域。
T79904	PROTAC CDK9/CycT1 Degrader-2 化合物 PROTAC CDK9/CycT1 Degrader-2		98%
T79904	PROTACCDK9/CycT1 Degrader-2 对CDK9表现出较高的抑制效能，具有一个IC50值为45 nM。
T82757	CDK9-IN-29 化合物 CDK9-IN-29	2737262-24-5	98%
T82757	CDK9-IN-29，一有效CDK9抑制剂(IC50=3.20 nM)，激酶选择性佳，能抑制细胞增殖及诱导细胞凋亡。
T82758	CDK9-Cyclin T1 PPI-IN-1 化合物 CDK9-Cyclin T1 PPI-IN-1		98%
T82758	CDK9-Cyclin T1 PPI-IN-1 (Compound B19) 是CDK9-Cyclin T1蛋白-蛋白相互作用的选择性抑制剂。该化合物能够有效抑制TNBC MDA-MB-231细胞系的细胞增殖(IC50: 0.044 μM)，诱导细胞凋亡，同时降低CDK9的转录活性并减少RNA Pol II CTD se...
T82759	CDK2-IN-20 化合物 CDK2-IN-20		98%
T82759	CDK2-IN-20 是一种对CDK2具有抑制作用的化合物。该化合物对肿瘤细胞表现出细胞毒性，其半抑制浓度(IC50)介于5.52至17.09 µM之间。CDK2-IN-20 作用于MCF-7细胞，能够引起细胞周期在S期的阻滞，并诱导细胞发生凋亡。
T10737	CDK4/6-IN-3 化合物 T10737	2366237-37-6	98%
T10737	CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
T16038	Men 10376 化合物 T16038	135306-85-3	98%
T16038	Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.
TN4263	Isoangustone A 化合物 TN4263	129280-34-8	98%
TN4263	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
T11309	FMF-04-159-2 化合物 T11309	2364489-81-4	98%
T11309	FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor.
T10739	CDK8/19-IN-1 化合物 T10739	1818427-07-4	98%
T10739	CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).
T15730	Ribociclib hydrochloride 瑞博西尼盐酸盐	1211443-80-9	98%
T15730	Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1...
T13425	(1S,3R,5R)-PIM447 dihydrochloride 化合物 T13425	T13425	98%
T13425	(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).
T11656	Indoramin D5 化合物 T11656	57165-41-0	98%
T11656	Indoramin D5 is a piperidine antiadrenergic agent. Indoramin D5 is deuterium labeled Indoramin.