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Search Results for " mdm2 "

Targets Recommended: Mdm2 Mdm2 p53

114

抑制剂 & 化合物

6

天然产物

21

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T72026	p53-MDM2-IN-1	Mdm2; p53	Apoptosis
	p53-MDM2-IN-1 (Example 30) 是一种 p53-MDM2/X 蛋白相互作用的抑制剂，Ki 值为 23.35 µM。p53-MDM2-IN-1 能用于抗肿瘤研究。
T67698	p53-Mdm2 inhibitor 4	Mdm2; p53	Apoptosis
	p53-Mdm2 inhibitor 4 抑制 p53-MDM2 蛋白质-蛋白质相互作用。
T41084	MDM2-IN-21 MDM2-IN-21
	MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer.
T24440	MDM2-p53-IN-1b MDM2-p53 inhibitor 1b,MDM2 p53 IN 1b
	MDM2-p53-IN-1b is the MDM2-p53 interaction inhibitor.
T12351	p53 and MDM2 proteins-interaction-inhibitor (racemic) p53-and-mdm2-proteins-interaction-inhibitor-racemic	Others	Others
	p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.
T18633	PROTAC MDM2 Degrader-3	Others	Others
	PROTAC MDM2 Degrader-3 is a compound that leverages PROTAC technology to degrade MDM2. It consists of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
T11982	MDM2-IN-1	Others	Others
	MDM2-IN-1 is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration.
T18631	PROTAC MDM2 Degrader-1	Others	Others
	PROTAC MDM2 Degrader-1 is a chemical compound that utilizes PROTAC technology to degrade MDM2. This compound is comprised of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
T18634	PROTAC MDM2 Degrader-4	Others	Others
	PROTAC MDM2 Degrader-4 is a compound designed using PROTAC technology to degrade MDM2. It combines a powerful MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
T18632	PROTAC MDM2 Degrader-2	Others	Others
	PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2, a linker, and the MDM2 ligand for E3 ubiquitin ligase, this compound facilitates the degradation of MDM2[1].
T12350	p53 and MDM2 proteins-interaction-inhibitor dihydrochloride	Others	Others
	p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.
T82179	HOXB7 8–25 MDM2 32-46
	HOXB7 8–25 (MDM2 32-46)为来源于MDM2的肽段，能够特异性诱导抗原和激活肿瘤反应性的CD4+ T细胞。
T17874	Nutlin carboxylic acid MDM2 ligand 1,E3 ligase Ligand 16	Others	Others
	Nutlin Carboxylic Acid (MDM2 ligand 1), derived from Nutlin 3, serves as an MDM2 ligand. It can be attached to a protein ligand via a linker to create PROTACs[1].
T79483	MDM2/XIAP-IN-3
	MDM2/XIAP-IN-3（化合物 3e）为MDM2/XIAP双重抑制剂，能够下调MDM2与XIAP蛋白水平，提升p53表达，进而抑制癌细胞增殖并诱导细胞凋亡。
T17873	(4R,5S)-nutlin carboxylic acid E3 ligase Ligand 15,MDM2 ligand 2	Others	Others
	(4R,5S)-Nutlin Carboxylic Acid (MDM2 Ligand 2), a Nutlin 3-based MDM2 ligand, can be conjugated to a protein-binding ligand via a linker to create PROTACs[1].
T81830	MDM2/XIAP-IN-1
	MDM2/XIAP-IN-1（compound 14）是一种口服活性的MDM2/XIAP双靶点抑制剂，展现出抗癌活性，其IC50值为0.3 μM，适用于癌症研究。
T79012	MDM2/XIAP-IN-2
	MDM2/XIAP-IN-2为MDM2（murine double minute 2）和XIAP（x-linked inhibitor of apoptosis protein）的双重抑制剂, 能够降解MDM2并抑制XIAP mRNA的翻译，进而抑制癌细胞生长。该化合物在针对急性淋巴细胞白血病细胞系EU-1的研究中显示出优秀的抑制效果，IC50值为0.3 μM。
T72832	MDM2-p53-IN-16
	MDM2-p53-IN-16 是MDM2-p53复合体抑制剂，其IC50值针对人MDM2-p532复合体为4.3 nM。该化合物能够重新激活p53，进而诱导多形性成胶质细胞瘤（GBM）细胞的凋亡和细胞周期阻滞，适用于癌症研究。
T74935	MDM2/4-p53-IN-2
	MDM2/4-p53-IN-2 (2q) 是一种有效的双重 MDM2/ MDM4抑制剂和 p53激活剂，作用于 MDM2-p53 和 MDM4-p53 复合物的 IC50值分别是 70.7 nM 和 81.4 nM。MDM2/4-p53-IN-2 可以调控细胞周期，诱导细胞凋亡(apoptosis)，具有抗癌活性。
T74936	MDM2/4-p53-IN-3
	MDM2/4-p53-IN-3，一种针对MDM2/4-p53蛋白-蛋白相互作用(PPI)的抑制剂，IC50s分别为18.5 nM（MDM2-p53）与14.8 nM（MDM4-p53）。该化合物主要应用于癌症研究领域，特别是结肠癌的研究。
T17902	Nutlin-C1-amido-PEG4-C2-N3 E3 ligase Ligand-Linker Conjugates 48,MDM2 Ligand-Linker Conjugates 1	Others	Others
	Nutlin-C1-amido-PEG4-C2-N3 is a novel compound that functions as a ligand-linker conjugate for the E3 ligase. It is a synthesized molecule incorporating the MDM2 ligand derived from Nutlin 3, and a 4-unit PEG linker. This compound is specifically designed for utilization in PROTAC technology.
T21578	NSC 66811	Mdm2	Apoptosis
	NSC 66811 是一种MDM2-p53抑制剂，其结合到 MDM2 的Ki 值为 120 nM。
T78699	MDMX/MDM2-IN-2
	MDMX/MDM2-IN-2 是一款p53-MDM2/MDMX双重抑制剂，具有高效性，其对MDM2和MDMX的Ki值分别为0.23 μM和2.45 μM。该化合物阻断p53与MDM2蛋白的相互作用，从而恢复p53功能，诱导细胞周期停滞与细胞凋亡。同时，MDMX/MDM2-IN-2抑制细胞迁移和侵袭，显示出潜在的抗肿瘤活性。
T1919	Tenovin-1 Tenovin 1	Mdm2; Dehydrogenase; Sirtuin; p53; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-1 抑制 SirT1 和 SirT2 的蛋白质去乙酰化活性，并防止 MDM2 介导的 p53 降解，这涉及泛素化。它具有癌症的研究潜力。
T63748	rel-MDM2/4-p53-IN-2
	rel-MDM2/4-p53-IN-2 (2q) 是有效的双重 MDM2/MDM4 抑制剂和 p53 激活剂，能够作用于 MDM2-p53 复合物 (IC50: 70.7 nM) 和 MDM4-p53 复合物 (IC50: 81.4 nM)。rel-MDM2/4-p53-IN-2 能够调控细胞周期，诱导细胞凋亡(apoptosis)，表现出抗癌效果。
T6610	XI-006 NSC 207895,可可碱	Mdm2; p53	Apoptosis
	XI-006 (XI-006) 是一种DNA 破坏剂、抗肿瘤剂和p53的激活剂。
T63438	rel-MDM2/4-p53-IN-3
	rel-MDM2/4-p53-IN-3 是 MDM2/4-p53 蛋白质-蛋白质相互作用 (PPI) 抑制剂，能够作用于MDM2-p53、MDM4-p53，其IC50值分别为18.5 nM、14.8 nM。rel-MDM2/4-p53-IN-3 能够用于研究癌症，如结肠癌。
T1818	Tenovin-6 Tenovin 6	Dehydrogenase; Sirtuin; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-6 是 Tenovin-1 的类似物，能抑制二氢乳清酸脱氢酶。它也抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC50分别为 21 μM、10 μM 和 67 μM。它是一种 p53转录活性的激活剂。
T8480	Tenovin-6 Hydrochloride	Dehydrogenase; Sirtuin; HDAC; p53; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-6 Hydrochloride 是 Tenovin-1 的类似物，能抑制二氢乳清酸脱氢酶。它是一种 p53转录活性的激活剂，抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC50分别为 21 μM、10 μM 和 67 μM。
T6023	Nutlin-3a (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3	Apoptosis; E1/E2/E3 Enzyme; Autophagy	Apoptosis; Autophagy; Ubiquitination
	Nutlin-3a ((−)-Nutlin-3) 是 Nutlin-3 的活性对映体，是一种 MDM2抑制剂，可抑制 MDM2-p53相互作用，稳定 p53 蛋白，从而诱导细胞自噬和凋亡，有潜力研究 TP53野生型卵巢癌。
T6614	Nutlin-3b (+)-Nutlin-3,4-[[(4R,5S)-4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	Nutlin-3b ((+)-Nutlin-3) 是一种 p53/MDM2 拮抗剂或抑制剂，IC50为 13.6 μM。它与 MDM2 的结合活性比 Nutlin-3a 低 150 倍。
T2158	Nutlin-3 Nutlin3	E1/E2/E3 Enzyme	Ubiquitination
	Nutlin-3 是一种 MDM2 拮抗剂，抑制 MDM2-p53 相互作用，Ki 为 90 nM，并激活 p53。
T16771	RO-5963	Mdm2; p53	Apoptosis
	RO-5963是p53-MDM2和p53-MDMX 的双重抑制剂（IC50s:~17nM 和~24nM）。
TQ0127	Navtemadlin AMG232,CS-1300	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	Navtemadlin (AMG232) 是一种有效的、选择性的、可口服的 p53-MDM2 相互作用抑制剂，IC50值为 0.6 nM。它以 0.045 nM 的 Kd 与 MDM2 结合。
T6254	Idasanutlin RG7388,Ro 5503781,依达奴林	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	Idasanutlin (Ro 5503781) 是一种有效且特异性的 p53-MDM2 抑制剂，IC50值为 6 nM。
T3653	MX69	Mdm2; E1/E2/E3 Enzyme; IAP	Apoptosis; Ubiquitination
	MX69 是用于抗癌研究的一种MDM2/XIAP 抑制剂。
T14303	Alrizomadlin APG-115,AA-115	Mdm2	Apoptosis
	Alrizomadlin (APG-115) 是一种具有口服活性的 MDM2 抑制剂，IC50 为 3.8 nM，Ki 分别为 1 nM[1]。 Alrizomadlin 阻断 MDM2 和 p53 的相互作用，并以 p53 依赖性方式诱导细胞周期停滞和细胞凋亡。
T21773	SP-141 SP 141	Mdm2	Apoptosis
	SP-141 是一种 MDM2 抑制剂，可促进 MDM2 自身泛素化和降解，具有抗癌活性。
TQ0231	NVP-CGM097 CGM097	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	NVP-CGM097 (CGM097) 是一种选择性MDM2抑制剂，对hMDM2的IC50为 1.7 nM。
T6585	SAR405838 MI773,MI 773,MI-77301,MI-773	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SAR405838 (MI 773) 是 MI-773 的类似物，具有抗肿瘤活性。它是一种高效、选择性的MDM2-p53相互作用抑制剂，与 MDM2 结合的Ki 值为 0.88 nM。
T6965	RG7112 RG-7112,RG 7112,RO5045337	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	RG7112 (RO5045337) 是一种口服生物可利用的选择性 p53-MDM2 抑制剂。
T3517	RO8994	Mdm2; E1/E2/E3 Enzyme; p53	Apoptosis; Ubiquitination
	RO8994是一种高效且特异性的螺吲哚酮小分子 MDM2 抑制剂，MTT 增殖试验和HTRF 结合试验的IC50 为 20 nM 和 5 nM。
T11980	MD-224	Mdm2; E1/E2/E3 Enzyme; PROTACs	Apoptosis; PROTAC; Ubiquitination
	MD-224是一种基于蛋白水解靶向嵌合体（PROTAC）概念的高效、高效的MDM2降解剂，是一类新型抗癌剂。
T5555	Siremadlin NVP-HDM 201	E1/E2/E3 Enzyme	Ubiquitination
	Siremadlin (NVP-HDM 201) 是一种有效的、可口服的、高度特异性的 p53-MDM2 相互作用抑制剂。
T28509	RDR03871 RDR 03871,ZINC20458540,RDR-03871	Mdm2	Apoptosis
	RDR03871是一种 MDM2抑制剂。
T5461	GNE-6640	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	GNE 6640 是一种选择性泛素特异性肽酶 7(USP7)的非共价抑制剂，其对全长USP7、USP7 催化结构域、全长USP43 以及 Ub-MDM2 的IC50值分别为 0.75 μM、0.43 μM、20.3 μM 和 0.23 μM。
T28078	MMRi64	Apoptosis; Mdm2; p53	Apoptosis
	MMRi64 是 Mdm2-MdmX E3 连接酶活性的特异性抑制剂。MMRi64 能有效诱导 p53 积累，并诱导白血病/淋巴瘤细胞中 p53 途径的凋亡，破坏 Mdm2-MdmX 相互作用，下调白血病细胞中的 Mdm2 和 MdmX。MMRi64 MMRi64 可用于癌症研究。
T6149	YH239-EE	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	YH239-EE 是 YH239 的乙酯，是 p53-MDM2 拮抗剂和凋亡诱导剂。
T12040	Milademetan RAIN-32,DS-3032,DS3032b	Mdm2; Others	Apoptosis; Others
	Milademetan (DS-3032) 是一种具有口服活性和有效性的 MDM2 抑制剂，具有抗肿瘤活性，诱导 G1 细胞周期阻滞、衰老和凋亡。Milademetan 可用于研究急性髓系白血病和实体肿瘤。
T1493	BH3I-1 BHI1	BCL; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	BH3I-1 (BHI1) 是一种Bcl-2家族拮抗剂，作用于p53/mDM2，Kd 为 5.3 μM。它抑制BakBH3 肽与Bcl-xL 结合，Ki 为 2.6 μM。

化合物

p53-MDM2-IN-1

Cat.No: T72026

Target: Mdm2, p53

p53-Mdm2 inhibitor 4

Cat.No: T67698

Target: Mdm2, p53

Cat.No: T41084

Synonym: MDM2-IN-21

MDM2-p53-IN-1b

Cat.No: T24440

Synonym: MDM2-p53 inhibitor 1b,MDM2 p53 IN 1b

p53 and MDM2 proteins-interaction-inhibitor (racemic)

Cat.No: T12351

Synonym: p53-and-mdm2-proteins-interaction-inhibitor-racemic

Target: Others

PROTAC MDM2 Degrader-3

Cat.No: T18633

Target: Others

Cat.No: T11982

Target: Others

PROTAC MDM2 Degrader-1

Cat.No: T18631

Target: Others

PROTAC MDM2 Degrader-4

Cat.No: T18634

Target: Others

PROTAC MDM2 Degrader-2

Cat.No: T18632

Target: Others

p53 and MDM2 proteins-interaction-inhibitor dihydrochloride

Cat.No: T12350

Target: Others

Cat.No: T82179

Synonym: MDM2 32-46

Nutlin carboxylic acid

Cat.No: T17874

Synonym: MDM2 ligand 1,E3 ligase Ligand 16

Target: Others

MDM2/XIAP-IN-3

Cat.No: T79483

(4R,5S)-nutlin carboxylic acid

Cat.No: T17873

Synonym: E3 ligase Ligand 15,MDM2 ligand 2

Target: Others

MDM2/XIAP-IN-1

Cat.No: T81830

MDM2/XIAP-IN-2

Cat.No: T79012

MDM2-p53-IN-16

Cat.No: T72832

MDM2/4-p53-IN-2

Cat.No: T74935

MDM2/4-p53-IN-3

Cat.No: T74936

Nutlin-C1-amido-PEG4-C2-N3

Cat.No: T17902

Synonym: E3 ligase Ligand-Linker Conjugates 48,MDM2 Ligand-Linker Conjugates 1

Target: Others

Cat.No: T21578

Target: Mdm2

MDMX/MDM2-IN-2

Cat.No: T78699

Cat.No: T1919

Synonym: Tenovin 1

Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy

rel-MDM2/4-p53-IN-2

Cat.No: T63748

Cat.No: T6610

Synonym: NSC 207895,可可碱

Target: Mdm2, p53

rel-MDM2/4-p53-IN-3

Cat.No: T63438

Cat.No: T1818

Synonym: Tenovin 6

Target: Dehydrogenase, Sirtuin, Autophagy

Tenovin-6 Hydrochloride

Cat.No: T8480

Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy

Cat.No: T6023

Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3

Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy

Cat.No: T6614

Synonym: (+)-Nutlin-3,4-[[(4R,5S)-4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T2158

Synonym: Nutlin3

Target: E1/E2/E3 Enzyme

Cat.No: T16771

Target: Mdm2, p53

Cat.No: TQ0127

Synonym: AMG232,CS-1300

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T6254

Synonym: RG7388,Ro 5503781,依达奴林

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T3653

Target: Mdm2, E1/E2/E3 Enzyme, IAP

Cat.No: T14303

Synonym: APG-115,AA-115

Target: Mdm2

Cat.No: T21773

Synonym: SP 141

Target: Mdm2

Cat.No: TQ0231

Synonym: CGM097

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T6585

Synonym: MI773,MI 773,MI-77301,MI-773

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T6965

Synonym: RG-7112,RG 7112,RO5045337

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T3517

Target: Mdm2, E1/E2/E3 Enzyme, p53

Cat.No: T11980

Target: Mdm2, E1/E2/E3 Enzyme, PROTACs

Cat.No: T5555

Synonym: NVP-HDM 201

Target: E1/E2/E3 Enzyme

Cat.No: T28509

Synonym: RDR 03871,ZINC20458540,RDR-03871

Target: Mdm2

Cat.No: T5461

Target: DUB

Cat.No: T28078

Target: Apoptosis, Mdm2, p53

Cat.No: T6149

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T12040

Synonym: RAIN-32,DS-3032,DS3032b

Target: Mdm2, Others

Cat.No: T1493

Synonym: BHI1

Target: BCL, E1/E2/E3 Enzyme

Cat. No.	Product Name	Target	Signaling Pathways
T6S1780	Protosappanin B 原苏木素B,Q-100961,FT-0689654	Apoptosis	Apoptosis
	Protosappanin B (Q-100961) 是从苏木中提取的一种多酚类天然产物，具有抗肿瘤作用。它通过激活 MDM2 依赖性泛素化过程诱导 p53 蛋白降解。它显著提高细胞活力，抑制细胞凋亡并上调生长相关蛋白 43 的表达。
T2140	Parthenolide (-)-Parthenolide,小白菊内酯	Apoptosis; Mitophagy; NF-κB; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κB
	Parthenolide ((-)-Parthenolide) 是一种从药草短舌匹菊中发现的倍半萜内酯。它抑制NF-κB 活化，有抗炎活性。它还可抑制HDAC1蛋白，但不影响其他I/II 类HDAC。
T6717	Vanillin Lioxin,m-Methoxy-p-hydroxybenzaldehyde,香草醛,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,香兰素,FEMA 3107	Others; Endogenous Metabolite	Metabolism; Others
	Vanillin (Zimco) 是一种天然产物，是从香草豆中提取的单个分子，是香水，食品和药物中广泛使用的气味。
T22857	Illudin S	Apoptosis; DNA Alkylator/Crosslinker; Antifungal	Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology
	Illudin S (ILS)是一种真菌倍半萜次生代谢物，具有很强的遗传毒性和细胞毒性
T2179	Triptolide PG490,NSC 163062,雷公藤甲素	Apoptosis; Mdm2; HSP; NF-κB	Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB
	Triptolide (PG490) 属于三环二萜类天然产物，是一种 NF-κB 活化的抑制剂。Triptolide 具有免疫抑制、抗风湿、抗炎、抗增殖和抗肿瘤活性。
TN4107	Ganoderic acid X	ERK; Mdm2; MAPK; Caspase; Topoisomerase; JNK; p53	Apoptosis; DNA Damage/DNA Repair; MAPK; Proteases/Proteasome
	Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.

天然产物

Protosappanin B

Cat.No: T6S1780

Synonym: 原苏木素B,Q-100961,FT-0689654

Target: Apoptosis

Cat.No: T2140

Synonym: (-)-Parthenolide,小白菊内酯

Target: Apoptosis, Mitophagy, NF-κB, HDAC, Autophagy

Cat.No: T6717

Synonym: Lioxin,m-Methoxy-p-hydroxybenzaldehyde,香草醛,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,香兰素,FEMA 3107

Target: Others, Endogenous Metabolite

Cat.No: T22857

Target: Apoptosis, DNA Alkylator/Crosslinker, Antifungal

Cat.No: T2179

Synonym: PG490,NSC 163062,雷公藤甲素

Target: Apoptosis, Mdm2, HSP, NF-κB

Ganoderic acid X

Cat.No: TN4107

Target: ERK, Mdm2, MAPK, Caspase, Topoisomerase, JNK, p53

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02630	MDM2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself, ARRB1 and ARBB2. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitina...
TMPY-04753	IRE1 Protein, Human, Recombinant (aa 465-977) hIRE1p,endoplasmic reticulum to nucleus signaling 1,IRE1P,IR...	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces...
TMPY-04413	IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) hIRE1p,endoplasmic reticulum to nucleus signaling 1,IRE1P,IR...	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces...
TMPY-01463	USP7 Protein, Human, Recombinant (aa 208-560, His & GST) ubiquitin specific peptidase 7 (herpes virus-associated),HAU...	Human	Baculovirus-Insect Cells
	Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein that belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase cor...
TMPH-02286	USP7 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and ...
TMPH-01855	PEX19 Protein, Human, Recombinant (GST)	Human	E. coli
	Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
TMPJ-00703	Gankyrin Protein, Human, Recombinant PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulator...	Human	E. coli
	Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
TMPY-01464	USP7 Protein, Human, Recombinant (aa 208-560) TEF1,HAUSP,ubiquitin specific peptidase 7 (herpes virus-asso...	Human	Baculovirus-Insect Cells
	Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein that belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase cor...
TMPY-01465	USP7 Protein, Human, Recombinant (His & GST) HAUSP,ubiquitin specific peptidase 7 (herpes virus-associate...	Human	Baculovirus-Insect Cells
	Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein that belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase cor...
TMPH-02899	VRK1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its rel...
TMPH-00900	Human adenovirus C serotype 5 Early E1A protein (His & SUMO)	HAdV-5	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regu...
TMPY-02228	p53 Protein, Cynomolgus, Recombinant tumor protein p53,p53,TP53	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag...
TMPY-01125	MDMX Protein, Human, Recombinant (His) MRP1,MDM4, p53 regulator,HDMX,MDMX	Human	E. coli
	MDM4 (MDM4 Regulator Of P53, also known as MDMX) is a Protein Coding gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows structural similarity to p53-binding protein MDM2. MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function. MDM4, an essential negative regulator of the P53 tumor ...
TMPY-04560	VRK1 Protein, Human, Recombinant (His & GST) PCH1A,PCH1,vaccinia related kinase 1	Human	Baculovirus-Insect Cells
	VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Serine/threonine protein kinases are tumor suppressor that controls the activity of AMP-activated protein kinase family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. VRK1 contains 1 protein kinase domain and localizes to the nucleus. VRK1 gene is widely expressed in human tissues and has increased expression in activel...
TMPY-02391	SUMO1 Protein, Human, Recombinant (His) small ubiquitin-like modifier 1,SMT3C,SMT3,SMT3H3,UBL1,SENP<...	Human	E. coli
	Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX act...
TMPH-02549	FHIT Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate. Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monop...
TMPY-02211	USP5 Protein, Human, Recombinant (His) ISOT,ubiquitin specific peptidase 5 (isopeptidase T)	Human	Baculovirus-Insect Cells
	Ubiquitin carboxyl-terminal hydrolase 5, also known as Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin-specific-processing protease 5, ISOT and USP5, is a member of the peptidase C19 family. USP5 contains 2 UBA domains and one UBP-type zinc finger. The UBP-type zinc finger domain interacts selectively with an unmodified C-terminus of the proximal ubiquitin. Both UBA domains are involved in polyubiquitin recognition. The UBP-type zinc finger domain crystallizes as ...
TMPY-04751	VRK1 Protein, Human, Recombinant PCH1,vaccinia related kinase 1,PCH1A	Human	Baculovirus-Insect Cells
	VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Serine/threonine protein kinases are tumor suppressor that controls the activity of AMP-activated protein kinase family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. VRK1 contains 1 protein kinase domain and localizes to the nucleus. VRK1 gene is widely expressed in human tissues and has increased expression in activel...
TMPH-02855	PML Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosp...
TMPH-00855	RPS3 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. ...
TMPH-02288	UBE2D3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by...

重组蛋白

MDM2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02630

Species: Mouse

Expression System: E. coli

IRE1 Protein, Human, Recombinant (aa 465-977)

Cat.No: TMPY-04753

Species: Human

Expression System: Baculovirus-Insect Cells

IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)

Cat.No: TMPY-04413

Species: Human

Expression System: Baculovirus-Insect Cells

USP7 Protein, Human, Recombinant (aa 208-560, His & GST)

Cat.No: TMPY-01463

Species: Human

Expression System: Baculovirus-Insect Cells

USP7 Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02286

Species: Human

Expression System: E. coli

PEX19 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01855

Species: Human

Expression System: E. coli

Gankyrin Protein, Human, Recombinant

Cat.No: TMPJ-00703

Species: Human

Expression System: E. coli

USP7 Protein, Human, Recombinant (aa 208-560)

Cat.No: TMPY-01464

Species: Human

Expression System: Baculovirus-Insect Cells

USP7 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01465

Species: Human

Expression System: Baculovirus-Insect Cells

VRK1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02899

Species: Mouse

Expression System: E. coli

Human adenovirus C serotype 5 Early E1A protein (His & SUMO)

Cat.No: TMPH-00900

Species: HAdV-5

Expression System: E. coli

p53 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-02228

Species: Cynomolgus

Expression System: E. coli

MDMX Protein, Human, Recombinant (His)

Cat.No: TMPY-01125

Species: Human

Expression System: E. coli

VRK1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04560

Species: Human

Expression System: Baculovirus-Insect Cells

SUMO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02391

Species: Human

Expression System: E. coli

FHIT Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02549

Species: Mouse

Expression System: E. coli

USP5 Protein, Human, Recombinant (His)

Cat.No: TMPY-02211

Species: Human

Expression System: Baculovirus-Insect Cells

VRK1 Protein, Human, Recombinant

Cat.No: TMPY-04751

Species: Human

Expression System: Baculovirus-Insect Cells

PML Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02855

Species: Mouse

Expression System: E. coli

RPS3 Protein, Human, Recombinant (His)

Cat.No: TMPH-00855

Species: Human

Expression System: E. coli

UBE2D3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02288

Species: Human

Expression System: E. coli

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