Antiviral agent 15

Antiviral agent 15 (Compound 15f) 是一种 Clofazimine 衍生物，具有抗病毒活性。Antiviral agent 15 能够抑制狂犬病病毒 (EC50: 1.45 μM) 和假型 SARS-CoV-2 (EC50: 14.6 μM)。

TP prodrug (compound 15) 是一种高效且具口服活性的抗SARS-CoV-2化合物。13-TP前药显示出细胞毒性，并能够降低SARS-CoV-2 N蛋白的表达，同时具备抗病毒活性。

Caffeoylcalleryanin demonstrated potent inhibitory activity against 15-lipoxygenase (15-LOX), with an IC50 value of 1.59 μM. Furthermore, ethanol extract from A. pulchra leaves (EEAPL) was found to contain compounds exhibiting antiviral properties, particularly effective against Dengue virus type 2 (DENV-2). Among these compounds, Caffeoylcalleryanin emerged as the most potent anti-DENV-2 agent, achieving a selectivity index (SI) of 20.0.

Conalbumin（伴清蛋白，ovotransferrin）是一种蛋清蛋白和糖蛋白，作为转铁蛋白和金属蛋白酶家族的一员，具有抗菌、抗氧化和免疫调节的特性。在pH为7或更高时，Conalbumin对于Fe3+的结合对数为15。