PROTAC Selection

Cat. No.	Product Name	CAS No.	Purity
T10485	PROTAC Bcl2 degrader-1 化合物 T10485	2378801-85-3	98%
T10485	PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
T12027	MG-277 化合物 T12027	T12027	98%
T12027	MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
T13844	PROTAC K-Ras Degrader-1 化合物 T13844	2378258-52-5	98%
T13844	PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
T18597	DFKBP-1 化合物 T18597	1799711-22-0	98%
T18597	dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].
T17996	VH032-PEG5-C6-Cl 化合物 T17996	1799506-06-1	98%
T17996	VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of...
T18632	PROTAC MDM2 Degrader-2 化合物 T18632	2249944-99-6	98%
T18632	PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2,...
T17995	Halo PROTAC 1 化合物 T17995	2241668-45-9	98%
T17995	Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce au...
T5439	BRD4 degrader AT1 化合物BRD4 degrader AT1	2098836-45-2	98%
T5439	BRD4 degrader AT1 是基于 PROTAC 技术的高选择性 Brd4 降解剂，在细胞中对 Brd4BD2 的 Kd 为 44 nM。
T10875	CP5V 化合物 T10875	2509359-75-3	98%
T10875	CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ...
T18598	PROTAC BRD2/BRD4 degrader-1 化合物 T18598	T18598	98%
T18598	PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly sel...
T13685	ERD-308 化合物 T13685	2320561-35-9	98%
T13685	ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM an...
T11441	GNE-987 化合物 T11441	2417371-71-0	98%
T11441	GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and...
T18682	SJFδ 化合物 T18682	2254609-23-7	98%
T18682	SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
T18061	KB02-SLF 化合物 T18061	T18061	98%
T18061	KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, a...
T13552	ARD-266 化合物 T13552	T13552	98%
T13552	ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-positi...
T13694	FKBP12 PROTAC RC32 化合物 T13694	2375555-66-9	98%
T13694	FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTA...
T41180	JQAD1 化合物JQAD1	2417097-18-6	99.75%
T41180	JQAD1是一种有效的、选择性的组蛋白乙酰转移酶 EP300降解剂（PROTAC；DC50≤31.6nM）；其包含 EP300抑制剂A485，通过连接体连接至脑啡肽E3连接酶配体。JQAD1以蛋白酶体依赖的方式导致神经母细胞瘤细胞系中EP300的降解。JQAD1抑制H3K27ac 和EP300的表达水平并诱导细胞凋亡。J...
T29106	VH032 化合物VH032	1448188-62-2	99.72%
T29106	VH032通常用作 PROTAC 的前体，作为 E3泛素连接酶组件连接 VHL，是一种与 KdPROTACs 相互作用的 VHL/HIF-1α抑制剂，作为von Hippel-Lindau (VHL)的配体招募VHL 蛋白。
T5435	ARV-771 化合物ARV-771	1949837-12-0	99.69%
T5435	ARV-771 是基于 PROTAC 技术的有效 BET 降解剂，对 BRD2(1)、BRD2(2)、BRD3(1)、BRD3(2)、BRD4 (1) 和 BRD4(2)的 Kd 分别为 34、4.7、8.3、7.6、9.6 和 7.6 nM。
T17069	THAL-SNS-032 化合物THAL-SNS-032	2139287-33-3	99.68%
T17069	THAL-SNS-032 是一种选择性 CDK 降解剂，由 CereblonE3 连接酶 (CRBN) 的配体 thalidomide 衍生物、CDK 配体 SNS-032和 linker 组成的 PROTAC 连接体。