PROTAC Selection

Cat. No.	Product Name	CAS No.	Purity
T13834	PROTAC BRD4 Degrader-2 化合物 T13834	2185795-53-1	98%
T13834	PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
T11975	PROTAC Mcl1 degrader-1 化合物 T11975	2163793-38-0	98%
T11975	PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide t...
T18636	PROTAC ERα Degrader-1 化合物 T18636	T18636	98%
T18636	PROTAC ERα Degrader-1 is a chemical compound. It consists of a ubiquitin E3 ligase binding group, a linker, and a protein binding group. This compound serves as ...
T13786	MZP-55 化合物 T13786	2010159-48-3	98%
T13786	MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
T13657	DMCL1-2 化合物 T13657	2351218-88-5	98%
T13657	dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, which binds to MCL1 with a KD of 30 nM. dmcl-2 activates the apoptos...
T12552	PROTAC CDK2/9 Degrader-1 化合物 T12552	2408641-24-5	98%
T12552	PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
T18604	PROTAC CRBN Degrader-1 化合物 T18604	2358775-70-7	98%
T18604	PROTAC CRBN Degrader-1 is a chemical compound consisting of a cereblon (CRBN) ligand binding group, a linker, and a von Hippel-Landau (VHL) binding group. It fun...
T18680	SD-36 化合物 SD-36	2429877-44-9	98%
T18680	SD-36, a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), exhibits high specificity for STAT3 over other STAT members. It effectively targets both wild-...
T13887	SJF620 化合物 T13887	2376187-16-3	98%
T13887	SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).
T13782	MS432 化合物 T13782	T13782	98%
T13782	MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
T17543	BI-3663 化合物 T17543	2341740-84-7	98%
T17543	BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3...
T13105	TD-428 化合物 T13105	T13105	98%
T13105	TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD...
T17926	(S,R,S)-AHPC-PEG6-C4-Cl 化合物 T17926	1835705-59-3	98%
T17926	(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capa...
T13840	PROTAC FAK degrader 1 化合物 T13840	2301916-69-6	98%
T13840	PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).
T13930	TL13-12 化合物 T13930	2229037-04-9	98%
T13930	TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).
T13833	PROTAC BRD4 Degrader-1 化合物 T13833	2133360-00-4	98%
T13833	PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
T13743	JH-XI-10-02 化合物 T13743	2209085-22-1	98%
T13743	JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrade...
T13845	PROTAC PARP1 degrader 化合物 T13845	2369022-68-2	98%
T13845	PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μ...
T12907	SIAIS178 化合物 T12907	2376047-73-1	98%
T12907	SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM).
T14318	ARCC-4 化合物 T14318	1973403-00-7	98%
T14318	ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degrad...