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PROTAC Selection

PROTAC Selection

Cat. No. Product Name CAS No. Purity Chemical Structure
T13929 TL13-112
化合物 T13929
2229037-19-6 98%
TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).
T11291 FKBP12 PROTAC dTAG-13
化合物 T11291
2064175-41-1 98%
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) al...
T12555 PROTAC FLT-3 degrader 1
化合物 T12555
2230826-81-8 98%
PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.
T13850 PROTAC BET degrader-3
化合物 T13850
T13850 98%
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
T18606 PROTAC ER Degrader-2
化合物 T18606
T18606 98%
PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequent...
T17728 PROTAC CDK9 degrader-2
化合物 T17728
T17728 98%
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogoni...
T12554 PROTAC EED degrader-2
化合物 T12554
T12554 98%
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.
T17297 ZXH-3-26
化合物 T17297
2243076-67-5 98%
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
T13561 AT6
化合物 T13561
2098836-50-9 98%
AT6 is a PROTAC AT1 analog which is a highly selective bromodomain (Brd4) degrader.
T18609 PROTAC ERRα Degrader-2
化合物 T18609
2306388-85-0 98%
PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This comp...
T13781 MS4077
化合物 T13781
2230077-10-6 98%
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T18681 SJFα
化合物 T18681
2254609-27-1 98%
SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the o...
T18634 PROTAC MDM2 Degrader-4
化合物 T18634
2249750-24-9 98%
PROTAC MDM2 Degrader-4 is a compound designed using PROTAC technology to degrade MDM2. It combines a powerful MDM2 inhibitor, a linker, and the MDM2 ligand for E...
T12553 PROTAC EED degrader-1
化合物 T12553
T12553 98%
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.
T18610 PROTAC FKBP Degrader-3
化合物 T18610
2079056-43-0 98%
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrade...
T15484 HJB97
化合物HJB97
2093391-24-1 98%
HJB97 可用于开发设计 PROTAC BET 的降解剂,具有抗肿瘤活性。HJB97 是高亲和力的 BET 抑制剂,Ki 值分别为 0.9 nM (BRD2 BD1),0.27 nM (BRD2 BD2),0.18 nM (BRD3 BD1),0.21 nM (BRD3 BD2),0.5 nM (BRD4 BD1),1...
T18060 KB02-JQ1
化合物 T18060
T18060 98%
KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or...
T12798 (S)-GNE-987
化合物 T12798
T12798 98%
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
T13627 CP-10
化合物 T13627
2366268-80-4 98%
CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells inclu...
T12559 PROTAC BET degrader-2
化合物 T12559
2093388-33-9 98%
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).
TL13-112
T13929
TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).
FKBP12 PROTAC dTAG-13
T11291
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) al...
PROTAC FLT-3 degrader 1
T12555
PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.
PROTAC BET degrader-3
T13850
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
PROTAC ER Degrader-2
T18606
PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequent...
PROTAC CDK9 degrader-2
T17728
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogoni...
PROTAC EED degrader-2
T12554
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.
ZXH-3-26
T17297
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
AT6
T13561
AT6 is a PROTAC AT1 analog which is a highly selective bromodomain (Brd4) degrader.
PROTAC ERRα Degrader-2
T18609
PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This comp...
MS4077
T13781
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
SJFα
T18681
SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the o...
PROTAC MDM2 Degrader-4
T18634
PROTAC MDM2 Degrader-4 is a compound designed using PROTAC technology to degrade MDM2. It combines a powerful MDM2 inhibitor, a linker, and the MDM2 ligand for E...
PROTAC EED degrader-1
T12553
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.
PROTAC FKBP Degrader-3
T18610
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrade...
HJB97
T15484
HJB97 可用于开发设计 PROTAC BET 的降解剂,具有抗肿瘤活性。HJB97 是高亲和力的 BET 抑制剂,Ki 值分别为 0.9 nM (BRD2 BD1),0.27 nM (BRD2 BD2),0.18 nM (BRD3 BD1),0.21 nM (BRD3 BD2),0.5 nM (BRD4 BD1),1...
KB02-JQ1
T18060
KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or...
(S)-GNE-987
T12798
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
CP-10
T13627
CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells inclu...
PROTAC BET degrader-2
T12559
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).
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