Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T13929 | TL13-112
化合物 T13929
|
2229037-19-6 | 98% |
|
TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM). | ||||
T11291 | FKBP12 PROTAC dTAG-13
化合物 T11291
|
2064175-41-1 | 98% |
|
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) al... | ||||
T12555 | PROTAC FLT-3 degrader 1
化合物 T12555
|
2230826-81-8 | 98% |
|
PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity. | ||||
T13850 | PROTAC BET degrader-3
化合物 T13850
|
T13850 | 98% |
|
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC. | ||||
T18606 | PROTAC ER Degrader-2
化合物 T18606
|
T18606 | 98% |
|
PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequent... | ||||
T17728 | PROTAC CDK9 degrader-2
化合物 T17728
|
T17728 | 98% |
|
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogoni... | ||||
T12554 | PROTAC EED degrader-2
化合物 T12554
|
T12554 | 98% |
|
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11. | ||||
T17297 | ZXH-3-26
化合物 T17297
|
2243076-67-5 | 98% |
|
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM). | ||||
T13561 | AT6
化合物 T13561
|
2098836-50-9 | 98% |
|
AT6 is a PROTAC AT1 analog which is a highly selective bromodomain (Brd4) degrader. | ||||
T18609 | PROTAC ERRα Degrader-2
化合物 T18609
|
2306388-85-0 | 98% |
|
PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This comp... | ||||
T13781 | MS4077
化合物 T13781
|
2230077-10-6 | 98% |
|
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK). | ||||
T18681 | SJFα
化合物 T18681
|
2254609-27-1 | 98% |
|
SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the o... | ||||
T18634 | PROTAC MDM2 Degrader-4
化合物 T18634
|
2249750-24-9 | 98% |
|
PROTAC MDM2 Degrader-4 is a compound designed using PROTAC technology to degrade MDM2. It combines a powerful MDM2 inhibitor, a linker, and the MDM2 ligand for E... | ||||
T12553 | PROTAC EED degrader-1
化合物 T12553
|
T12553 | 98% |
|
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17. | ||||
T18610 | PROTAC FKBP Degrader-3
化合物 T18610
|
2079056-43-0 | 98% |
|
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrade... | ||||
T15484 | HJB97
化合物HJB97
|
2093391-24-1 | 98% |
|
HJB97 可用于开发设计 PROTAC BET 的降解剂,具有抗肿瘤活性。HJB97 是高亲和力的 BET 抑制剂,Ki 值分别为 0.9 nM (BRD2 BD1),0.27 nM (BRD2 BD2),0.18 nM (BRD3 BD1),0.21 nM (BRD3 BD2),0.5 nM (BRD4 BD1),1... | ||||
T18060 | KB02-JQ1
化合物 T18060
|
T18060 | 98% |
|
KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or... | ||||
T12798 | (S)-GNE-987
化合物 T12798
|
T12798 | 98% |
|
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC). | ||||
T13627 | CP-10
化合物 T13627
|
2366268-80-4 | 98% |
|
CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells inclu... | ||||
T12559 | PROTAC BET degrader-2
化合物 T12559
|
2093388-33-9 | 98% |
|
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ). |