Name: QO-83
Brand: TargetMol
SKU: T218037
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

10-14周

50 mg

待询

10-14周

生物活性

产品描述	QO-83, a retigabine analog, is an activator of the voltage-gated potassium channel KCNQ2 (Kv7.2) with an EC₅₀ of 0.56 μM. It binds to a single hydrophobic pocket of the KCNQ2-CaM complex in a closed conformation. QO-83 shifts the voltage-dependent activation curve of the KCNQ2 channel negatively, enhancing the channel's voltage sensitivity, and can be utilized in epilepsy research.
靶点活性 (IC₅₀)	Kv7.2 channel:0.56 μM (EC50)
体外活性	QO-83在20 μM处理1 h时结合于闭合构象的人源 KCNQ2-CaM 复合体PD结构域(S5-S6 界面)中的单一疏水口袋，并诱导PD结构域与VSD结构域(S3-S4 界面)发生构象重排；在10 μM时，QO-83使电压依赖性激活曲线向负方向偏移。

化学信息

分子量	423.45
分子式	C₂₂H₂₅F₄N₃O
CAS No.	2253948-15-9
Smiles	O=C(NC1=CC=C(NCC2=CC=C(C=C2)C(F)(F)F)C(F)=C1N)CCC3CCCC3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

QO-83