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TB5

TB5

产品编号 T3596   CAS 948841-07-4

TB5 是一种选择性可逆 hMAO-B 有效抑制剂,Ki=0.11±0.01 μM。

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TB5 Chemical Structure
TB5, CAS 948841-07-4
规格 价格/CNY 货期 数量
5 mg ¥ 397 现货
10 mg ¥ 666 现货
25 mg ¥ 1,254 现货
50 mg ¥ 1,995 现货
100 mg ¥ 3,187 现货
1 mL * 10 mM (in DMSO) ¥ 448 现货
产品目录号及名称: TB5 (T3596)
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纯度: 99.82%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 TB5 is a potent, selective and reversible inhibitor of hMAO-B.
靶点活性 hMAO-B:0.11±0.01 μM. (Ki)
体外活性 TB5 and TB8 interacts with the catalytic site of hMAO-B and hMAO-A with a competitive mode of inhibition. TB5 exhibits the best inhibitory activity and higher selectivity toward hMAO-B, with Ki and SI values of 0.11±0.01 μM and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A inhibition by compound TB8 are completely reversed after 24 h of dialysis. Cytotoxicity studies show TB5 is nontoxic at 5 and 25 μM with cell viabilities of 95.75% and 84.59 %, respectively[1].
体内活性 Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30). Kinetic analyses are carried out for TB5 and TB8 to understand the crucial interactions responsible for selectivity and potency. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1 μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8[1].
激酶实验 Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1 μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8[1].
细胞实验 In vitro cytotoxicity of brominated thiophene chalcones and standard MAO inhibitors are tested in human HepG2 hepatic cancer cells at three different concentrations (1, 5 and 25 μM)[1].
分子量 336.25
分子式 C15H14BrNOS
CAS No. 948841-07-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 55 mg/mL (163.57 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.974 mL 14.8699 mL 29.7398 mL 74.3494 mL
5 mM 0.5948 mL 2.974 mL 5.948 mL 14.8699 mL
10 mM 0.2974 mL 1.487 mL 2.974 mL 7.4349 mL
20 mM 0.1487 mL 0.7435 mL 1.487 mL 3.7175 mL
50 mM 0.0595 mL 0.2974 mL 0.5948 mL 1.487 mL
100 mM 0.0297 mL 0.1487 mL 0.2974 mL 0.7435 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Mathew B, et al. Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors. ChemMedChem. 2016 Jun 6;11(11):1161-71.
Allylthiourea Tyramine Furazolidone 2'-O-Methylperlatolic acid CHBO4 AChE/BChE/MAO-B-IN-1 Pargyline hydrochloride Eprobemide

相关化合物库

该产品包含在如下化合物库中:
神经退行性疾病化合物库 经典已知活性库 抗帕金森病化合物库 已知活性化合物库 细胞重编程化合物库 抗抑郁症化合物库 线粒体靶向库 神经信号分子库 抗代谢疾病化合物库 抑制剂库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

TB5 948841-07-4 Metabolism Neuroscience Monoamine Oxidase MAO TB 5 Inhibitor inhibit TB-5 inhibitor

 

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