Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rosabulin (STA 5312) 是一种具有口服活性的微管抑制剂,具有有效性。 Rosabulin 可抑制微管组装,具有广谱抗肿瘤活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,230 | 现货 | ||
5 mg | ¥ 3,130 | 现货 | ||
10 mg | ¥ 4,590 | 现货 | ||
25 mg | ¥ 7,290 | 现货 | ||
50 mg | ¥ 9,860 | 现货 | ||
100 mg | ¥ 13,200 | 现货 | ||
500 mg | ¥ 26,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,450 | 现货 |
产品描述 | v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency. Rosabulin inhibits microtubule assembly and has broad-spectrum antitumor activity. |
体外活性 | Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. Rosabulin is active against several tumor cell lines that express moderate to high levels of P-glycoprotein. Rosabulin shows substantial anti-proliferative activity against a wide range of cancer cell lines in vitro, with IC50 values extending down into the nanomolar range.[1] |
体内活性 | Rosabulin has displayed in vivo activity in several murine tumors as well as human tumor xenograft models.[1] |
别名 | STA 5312 |
分子量 | 400.45 |
分子式 | C22H16N4O2S |
CAS No. | 501948-05-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (62.43 mM), Sonification is recommended
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4972 mL | 12.486 mL | 24.9719 mL | 62.4298 mL |
5 mM | 0.4994 mL | 2.4972 mL | 4.9944 mL | 12.486 mL | |
10 mM | 0.2497 mL | 1.2486 mL | 2.4972 mL | 6.243 mL | |
20 mM | 0.1249 mL | 0.6243 mL | 1.2486 mL | 3.1215 mL | |
50 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2486 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Rosabulin 501948-05-6 Cytoskeletal Signaling Others Microtubule Associated STA-5312 STA 5312 STA5312 Inhibitor inhibitor inhibit