Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety. KDU731is an orally active C. parvum inhibitor of PI4K (IC50: 25 nM). KDU731 blocks Cryptosporidium infection in vitro and in vivo.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety. KDU731is an orally active C. parvum inhibitor of PI4K (IC50: 25 nM). KDU731 blocks Cryptosporidium infection in vitro and in vivo. |
体内活性 | KDU731 (p.o.; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed obviously fewer oocysts than vehicle-treated calves in their stool. KDU731 (p.o.; 7 or 10mg/kg; 16 days) has;effective activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding[2]. |
分子量 | 396.4 |
分子式 | C22H16N6O2 |
CAS No. | 1610610-48-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (210.22 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5227 mL | 12.6135 mL | 25.227 mL | 63.0676 mL |
5 mM | 0.5045 mL | 2.5227 mL | 5.0454 mL | 12.6135 mL | |
10 mM | 0.2523 mL | 1.2614 mL | 2.5227 mL | 6.3068 mL | |
20 mM | 0.1261 mL | 0.6307 mL | 1.2614 mL | 3.1534 mL | |
50 mM | 0.0505 mL | 0.2523 mL | 0.5045 mL | 1.2614 mL | |
100 mM | 0.0252 mL | 0.1261 mL | 0.2523 mL | 0.6307 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
KDU731 1610610-48-4 Others KDU 731 KDU-731 Inhibitor inhibitor inhibit