Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hycanthone (Etrenol(mesylate)) 是 Lucanthone 的生物活性代谢产物,是一种抗血吸虫病药。它是一个噻吨酮类 DNA 嵌入剂,可抑制 RNA 合成以及 DNA 拓扑异构酶 I 和 II。它通过直接蛋白质结合来抑制核酸生物合成并抑制嘌呤内切核酸酶1,KD 为 10 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 396 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 371 | 现货 |
产品描述 | Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits APE1 via direct protein binding(KD: 10 nM). |
靶点活性 | APE1:10 nM(Kd) |
体外活性 | Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Compared to that of controls, results show that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively decreases viral interferon yields as much as 73% [2]. |
体内活性 | Male worms treated with Hycanthone display signs of possible partial recovery from the initial low levels of incorporation. After treatment with Hycanthone, the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease. Immature worms are totally unaffected by Hycanthone at all times tested. In the first four days after treatment, incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50%. 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules [1]. |
别名 | Etrenol(mesylate), Win 249-33, 海恩酮 |
分子量 | 356.48 |
分子式 | C20H24N2O2S |
CAS No. | 3105-97-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 18 mg/mL (50.49 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8052 mL | 14.026 mL | 28.0521 mL | 70.1302 mL |
5 mM | 0.561 mL | 2.8052 mL | 5.6104 mL | 14.026 mL | |
10 mM | 0.2805 mL | 1.4026 mL | 2.8052 mL | 7.013 mL | |
20 mM | 0.1403 mL | 0.7013 mL | 1.4026 mL | 3.5065 mL | |
50 mM | 0.0561 mL | 0.2805 mL | 0.561 mL | 1.4026 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Hycanthone 3105-97-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology DNA/RNA Synthesis Topoisomerase Parasite APE1 inhibit acid intercalator Etrenol(mesylate) Lucanthone anti-schistosomal Win 249-33 nucleic apurinic endonuclease-1 biosynthesis Inhibitor thioxanthenone 海恩酮 inhibitor